Abstract
Objective
The objective was to evaluate the efficacy of diffusion-weighted imaging (DWI) in
predicting the development of vascularization in hypovascular hepatocellular lesions
(HHLs).
Materials and methods
Forty-two HHLs that were diagnosed by computed tomographic (CT) arteriography were
evaluated retrospectively. The lesion on DWI was classified as isointense, hypointense,
or hyperintense. Follow-up studies that included intravenous dynamic CT or magnetic
resonance imaging were performed.
Results
The 730-day cumulative developments of vascularization in hypointense, isointense,
and hyperintense lesions were 17%, 30%, and 40%, respectively. The differences among
these developments were not statistically significant.
Conclusion
The signal intensity on DWI showed no significant difference in the development of
vascularization.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Clinical ImagingAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Early stages of multistep hepatocarcinogenesis: adenomatous hyperplasia and early hepatocellular carcinoma.Hum Pathol. 1991; 22: 172-178
- Multicentric independent development of hepatocellular carcinoma revealed by analysis of hepatitis B virus integration pattern.Am J Surg Pathol. 1989; 13: 1064-1067
- Progression to hypervascular hepatocellular carcinoma: correlation with intranodular blood supply evaluated with CT during intraarterial injection of contrast material.Radiology. 2002; 225: 143-149
- Gd-EOB-DTPA enhanced MRI for hepatocellular carcinoma: quantitative evaluation of tumor enhancement in hepatobiliary phase.Magn Reson Med Sci. 2005; 4: 1-9
- Imaging study of early hepatocellular carcinoma: usefulness of gadoxetic acid-enhanced MR imaging.Radiology. 2011; 261: 834-844
- Diffusion-weighted imaging of surgically resected hepatocellular carcinoma: imaging characteristics and relationship among signal intensity, apparent diffusion coefficient, and histopathologic grade.AJR Am J Roentgenol. 2009; 193: 438-444
- Contribution of diffusion-weighted magnetic resonance imaging in the characterization of hepatocellular carcinomas and dysplastic nodules in cirrhotic liver.J Comput Assist Tomogr. 2010; 34: 506-512
- Gadoxetic acid-enhanced hepatobiliary phase MRI and high-b-value diffusion-weighted imaging to distinguish well-differentiated hepatocellular carcinomas from benign nodules in patients with chronic liver disease.AJR Am J Roentgenol. 2011; 197: W868-W875
- The effect of simultaneous use of respiratory triggering in diffusion-weighted imaging of the liver.Magn Reson Med Sci. 2006; 5: 129-136
- Respiratory gated diffusion-weighted imaging of the liver: value of apparent diffusion coefficient measurements in the differentiation between most commonly encountered benign and malignant focal liver lesions.Eur Radiol. 2008; 18: 486-492
- Respiratory-triggered versus breath-hold diffusion-weighted MRI of liver lesions: comparison of image quality and apparent diffusion coefficient values.AJR Am J Roentgenol. 2009; 192: 915-922
- Diffusion-weighted imaging of the liver: optimizing b value for the detection and characterization of benign and malignant hepatic lesions.J Magn Reson Imaging. 2008; 28: 691-697
- Optimal contrast dose for depiction of hypervascular hepatocellular carcinoma at dynamic CT using 64-MDCT.AJR Am J Roentgenol. 2008; 190: 1003-1009
- Abdominal helical CT: evaluation of optimal doses of intravenous contrast material–a prospective randomized study.Radiology. 2000; 216: 718-723
- High-b-value diffusion-weighted MR imaging of hepatocellular lesions: estimation of grade of malignancy of hepatocellular carcinoma.J Magn Reson Imaging. 2009; 30: 1005-1011
- Diagnostic discrepancy of early hepatocellular carcinoma between Japan and West.Hepatol Res. 2007; 37: S121-S124
- The influence of diffusion- and relaxation-related factors on signal intensity: an introductive guide to magnetic resonance diffusion-weighted imaging studies.J Comput Assist Tomogr. 2008; 32: 463-474
- The value of b required to avoid T2 shine-through from old lucunar infarcts in diffusion-weighted imaging.Neuroradiology. 2001; 43: 511-517
- Evolution of hypointense hepatocellular nodules observed only in the hepatobiliary phase of gadoxetate disodium-enhanced MRI.AJR Am J Roentgenol. 2011; 197: 58-63
- Early hepatocellular carcinoma and dysplastic nodules.Semin Liver Dis. 2005; 25: 133-142
- Hypovascular hypointense nodules on hepatobiliary phase gadoxetic acid-enhanced MR images in patients with cirrhosis: potential of DW imaging in predicting progression to hypervascular HCC.Radiology. 2012; 265: 104-114
- Usefulness of diffusion-weighted MRI with echo-planar technique in the evaluation of cellularity in gliomas.J Magn Reson Imaging. 1999; 9: 53-60
- Apparent diffusion coefficient value of diffusion-weighted imaging for hepatocellular carcinoma: correlation with the histologic differentiation and the expression of vascular endothelial growth factor.Korean J Radiol. 2010; 11: 295-303
- Vascular permeability factor: a unique regulator of blood vessel function.J Cell Biochem. 1991; 47: 219-223
- Expression of vascular endothelial growth factor in human hepatocellular carcinoma.Hepatology. 1998; 28: 68-77
- Increased expression of vascular endothelial growth factor and angiogenesis in the early stage of multistep hepatocarcinogenesis.Arch Pathol Lab Med. 2000; 124: 1061-1065
- Transient subsegmental hepatic parenchymal enhancement on dynamic CT: a sign of postbiopsy arterioportal shunt.J Comput Assist Tomogr. 1997; 21: 355-360
- Consensus report of the 2nd International Forum for Liver MRI.Eur Radiol. 2009; 19: S975-S989
Article info
Publication history
Published online: April 01, 2014
Accepted:
March 24,
2014
Received in revised form:
March 16,
2014
Received:
November 4,
2013
Footnotes
☆Disclosures: The authors have no financial disclosures associated with this study.
Identification
Copyright
© 2014 Elsevier Inc. Published by Elsevier Inc. All rights reserved.