Intramedullary spinal cord and leptomeningeal metastases from intracranial low-grade oligodendroglioma


      We present an unusual case of a patient with an intracranial low-grade oligodendroglioma who developed recurrence with an intramedullary spinal cord metastasis and multiple spinal leptomeningeal metastases. The intramedullary spinal cord metastasis showed mild enhancement similar to the original intracranial primary, while the multiple spinal leptomeningeal metastases revealed no enhancement. This is the seventh reported case of symptomatic intramedullary spinal cord metastasis from a low-grade oligodendroglioma.


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        • Kesari S
        • Batchelor TT
        Leptomeningeal metastases.
        Neurol Clin. 2003; 21: 25-66
        • Costigan DA
        • Winkelman MD
        Intramedullary spinal cord metastasis. A clinicopathological study of 13 cases.
        J Neurosurg. 1985; 62: 227-233
        • Yung WA
        • Horten BC
        • Shapiro WR
        Meningeal gliomatosis: a review of 12 cases.
        Ann Neurol. 1980; 8: 605-608
        • Moore MT
        • Eisinger G
        Extra primary seeding of glioblastoma multiforme in the subarachnoid space and ependyma.
        Neurology. 1963; 13: 855-865
        • Shahideh M
        • Fallah A
        • Munoz DG
        • et al.
        Systematic review of primary intracranial glioblastoma multiforme with symptomatic spinal metastases, with two illustrative patients.
        J Clin Neurosci. 2012; 19: 1080-1086
        • Engelhard HH
        Current diagnosis and treatment of oligodendroglioma.
        Neurosurg Focus. 2002; 12: E2
        • Elefante A
        • Peca C
        • Peca C
        • Del Basso De Caro ML
        • et al.
        Symptomatic spinal cord metastasis from cerebral oligodendroglioma.
        Neurol Sci. 2012; 33: 609-613
        • Godard J
        • Viennet G
        • Raul JS
        • et al.
        Intramedullary spread of a cerebral oligodendroglioma. Two case reports.
        Neuro-Chirurgie. 2000; 46: 558-562
        • Schiff D
        • O'Neill BP
        Intramedullary spinal cord metastases: clinical features and treatment outcome.
        Neurology. 1996; 47: 906-912
        • Zustovich F
        • Della Puppa A
        • Scienza R
        • et al.
        Metastatic oligodendrogliomas: a review of the literature and case report.
        Acta Neurochir (Wien). 2008; 150 ([discussion 702–693]): 699-702
        • Houillier C
        • Wang X
        • Kaloshi G
        • et al.
        IDH1 or IDH2 mutations predict longer survival and response to temozolomide in low-grade gliomas.
        Neurology. 2010; 75: 1560-1566