Abstract
Purpose
We investigated whether there are differences in metabolite ratios of different brain
regions between mild and severe obstructive sleep apnea (OSA) patients.
Materials and methods
A total of 17 mild OSA and 14 severe OSA patients were enrolled. N-acetyl aspartate (NAA)/creatine (Cr), choline (Cho)/Cr and NAA/Cho ratios were calculated
by using multivoxel magnetic resonance spectroscopy (MRS) (TR: 1500, TE: 135 ms) from
hippocampus, putamen, insular cortex, thalamus and temporal white matter. The relationship
between the two groups was evaluated with Mann–Whitney U test.
Results
NAA/Cr ratios obtained from hippocampus was found to be significantly increased in
severe OSA patients compared to mild OSA patients (P=.004). Cho/Cr ratios obtained from hippocampus and putamen in severe OSA patients
were significantly increased when compared to mild OSA patients (P=.003 and P=.004, respectively). In addition, NAA/Cho ratios of putamen were significantly decreased
in severe OSA patients when compared to mild OSA (P=.032).
Conclusion
MRS identified hypoxia-related metabolite and microstructural changes in hippocampus
and putamen. The metabolite changes of increase in NAA/Cr and Cho/Cr ratios and decrease
in NAA/Cho ratio were more pronounced with increasing severity of OSA syndrome.
Keywords
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Article info
Publication history
Published online: September 03, 2013
Accepted:
July 26,
2013
Received in revised form:
July 4,
2013
Received:
December 27,
2012
Footnotes
☆Conflict of interest statement: We declare that we have no conflict of interest.
Identification
Copyright
© 2013 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
