Abstract
To establish appropriate chest computed tomography (CT) acquisition protocols that
balance radiation dose and diagnostic capability in pediatric bone marrow transplant
patients by assessing the accuracy of pulmonary nodule detection at simulated lower-radiation
acquisitions, chest CT images from bone marrow transplant patients were reviewed by
four pediatric radiologists at artificially reduced CT dose levels (0%, 30%, and 60%).
Average accuracy for nodule detection in 31 randomly selected cases was 0.87 at 0%
dose reduction, 0.90 at 30% reduction, and 0.86 at 60% reduction. We observed no clinically
relevant difference in acceptability of images or accuracy levels with tested dose
reductions to 60%.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Clinical ImagingAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Health risks from exposure to low levels of ionizing radiation: Beir VII Phase 2. The National Academies Press, Washington DC2006
- Estimated risks of radiation-induced fatal cancer from pediatric CT.AJR. 2001; 176: 289-296
- American College of Radiology white paper on radiation dose in medicine.J Am Coll Radiol. 2007; 4: 272-284
- Computed tomography—an increasing source of radiation exposure.NEJM. 2007; 357: 277-2284
- Paediatric CT examinations in 19 developing countries: frequency and radiation dose.Radiat Prot Dosimetry. 2010; 140: 49-58
- Frequent body CT scanning of young adults: indications, outcomes, and risk for radiation-induced cancer.J Am Coll Radiol. 2011; 8: 501-507
- Cumulative ionizing radiation exposure in patients with end stage kidney disease: a 6-year retrospective analysis.Abdom Imaging. 2011; https://doi.org/10.1007/s00261-011-9786-x
- Cancer risks attributable to low doses of ionizing radiation: assessing what we really know.Proc Natl Acad Sci U S A. 2003; 100: 13761-13766
- National conference on dose reduction in CT, with an emphasis on pediatric patients.AJR. 2003; 181: 321-329
- Radiation dose and cancer risk from pediatric CT examinations on 64-slice CT: a phantom study.Eur J Radiol. 2010; 76: e19-e23
- Reply to commentary—CT radiation dose reduction: can we do harm by doing good?.Pediatr Radiol. 2012; 42: 399-401
- CT radiation dose reduction: can we do harm by doing good?.Pediatr Radiol. 2012; 42: 397-398
- Lung nodule detection in pediatric chest CT: quantitative relationship between image quality and radiologist performance.Med Phys. 2011; 38: 2609-2618
- Paediatric CT: the effects of increasing image noise on pulmonary nodule detection.Pediatr Radiol. 2008; 38: 192-201
- Pediatric MDCT: towards assessing the diagnostic influence of dose reduction on the detection of small lung nodules.Acad Radiol. 2009; 16: 872-880
- A pediatric CT dose and risk estimator.Pediatr Radiol. 2010; 40: 1816-1821
- Managing radiation use in medical imaging: a multifaceted challenge.Radiology. 2011; 258: 889-905
- Quality initiatives: CT radiation dose reduction: how to implement change without sacrificing diagnostic quality.Radiographics. 2011; 31: 1823-1832
- Value of axial and coronal maximum intensity projection (MIP) images in the detection of pulmonary nodules by multislice spiral CT: comparison with axial 1-mm and 5-mm slices.Eur Radiol. 2006; 16: 325-332
- Evaluation of optimal acquisition duration or injected activity for pediatric 18F-FDG PET/CT.J Nucl Med. 2011; 52: 1028-1034
- Accuracy of transmission CT and FDG-PET in the detection of small pulmonary nodules with integrated PET/CT.Eur J Nucl Med Mol Imaging. 2006; 33: 692-696
- Comparison of low dose and standard dose MDCT in detection of metastatic pulmonary nodules.J Med Assoc Thai. 2011; 94: 215-223
- Pulmonary nodules: effect of adaptive statistical iterative reconstruction (ASIR) technique on performance of a computer-aided detection (CAD) system—comparison of performance between different-dose CT scans.Eur J Radiol. 2011 Oct 5; ([Epub ahead of print])https://doi.org/10.1016/j.ejrad.2011.09.011
- Radiation dose of non-enhanced chest CT can be reduced 40% by using iterative reconstruction in image space.Clin Radiol. 2011; 66: 1023-1029
- Iterative reconstruction in head CT: image quality of routine and low-dose protocols in comparison with standard filtered back-projection..AJNR. 2012; 33: 218-224
- CT image quality improvement using adaptive iterative dose reduction with wide-volume acquisition on 320-detector CT.Eur Radiol. 2012; 22: 295-301
- Low-dose CT reconstruction via edge-preserving total variation regularization.Phys Med Biol. 2011; 56: 5949-5967
- Iterative reconstruction technique for reducing body radiation dose at CT: feasibility study.AJR. 2009; 193: 764-771
- Radiation dose reduction with hybrid iterative reconstruction for pediatric CT.Radiology. 2012; 263: 537-546
- Estimated additional lifetime risk of cancer attributable to diagnostic CT in a pediatric bone marrow transplant cohort: experience at a single academic institution.Open J Clin Diagnos. 2012; 2: 4-9
Article info
Publication history
Published online: June 06, 2012
Accepted:
April 19,
2012
Received:
April 4,
2012
Identification
Copyright
© 2013 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
