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Relationship between the degeneration of the cruciate ligaments and calcium pyrophosphate dihydrate crystal deposition: anatomic, radiologic study with histologic correlation

  • Author Footnotes
    1 Present address: Department of Radiology, Katip Celebi University Izmir Ataturk Research and Training Hospital, Turkey.
    Berna Dirim
    Correspondence
    Corresponding author. Soyak Mavisehir Yali Mahallesi Cihar Dudayev Bulvari 6523 sk 21, B4 Blok, Daire 42 Karsiyaka 35550 Turkey. Fax: +90 2322446269, +90 2322447282.
    Footnotes
    1 Present address: Department of Radiology, Katip Celebi University Izmir Ataturk Research and Training Hospital, Turkey.
    Affiliations
    Department of Radiology, University of California, San Diego, Veterans Affairs San Diego Healthcare System, San Diego, CA, USA
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  • Donald Resnick
    Affiliations
    Department of Radiology, University of California, San Diego, Veterans Affairs San Diego Healthcare System, San Diego, CA, USA
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  • Marcelo Abreu
    Affiliations
    Department of Radiology, University of California, San Diego, Veterans Affairs San Diego Healthcare System, San Diego, CA, USA
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  • Mani Wangwinyuvirat
    Affiliations
    Department of Radiology, University of California, San Diego, Veterans Affairs San Diego Healthcare System, San Diego, CA, USA
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  • Debra J. Trudell
    Affiliations
    Department of Radiology, University of California, San Diego, Veterans Affairs San Diego Healthcare System, San Diego, CA, USA
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  • Parviz Haghighi
    Affiliations
    Department of Radiology, University of California, San Diego, Veterans Affairs San Diego Healthcare System, San Diego, CA, USA
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  • Author Footnotes
    1 Present address: Department of Radiology, Katip Celebi University Izmir Ataturk Research and Training Hospital, Turkey.

      Abstract

      To investigate the association of calcium pyrophosphate dihydrate (CPPD) crystal deposition and cruciate ligament (CL) degeneration, 10 cadaveric knees were studied with 1.5-T magnetic resonance imaging and sectioned in three planes. The slices were evaluated with high-resolution Faxitron radiography. The images and specimens were evaluated by two radiologists. Histologic sections were obtained from eight that contained calcifications and from two without calcifications. Radiographs and histologic analysis demonstrated CPPD crystal deposition in 80% of specimens and 75% of CLs in these eight specimens. Degenerative changes were observed in 75% of them. Such analysis demonstrated no evidence of CPPD crystals or degeneration in the control specimens.

      Keywords

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      References

        • Steinbach LS
        • Resnick D
        Calcium pyrophosphate dihydrate crystal deposition disease revisited.
        Radiol. 1996; 200: 1-9
        • Martel W
        • McCarter DK
        • Solsky MA
        • et al.
        Further observations of the arthropathy of calcium pyrophosphate dihydrate crystal deposition disease.
        Radiology. 1981; 141: 1-15
        • Resnick CS
        • Resnick D
        Crystal deposition disease.
        Semin Arthritis Rheum. 1983; 12: 390-403
        • Yang BY
        • Sartoris D
        • Resnick D
        • et al.
        Calcium pyrophosphate dehydrate crystal deposition disease: frequency of tendon calcification about the knee.
        J Rheumatol. 1996; 23: 883-888
        • Abreu M
        • Johnson K
        • Chung CB
        • et al.
        Calcification in calcium pyrophosphate dihydrate (CPPD) crystalline deposits in the knee: anatomic, radiographic, MR imaging, and histologic study in cadavers.
        Skeletal Radiol. 2004; 33: 392-398
        • Cushner FD
        • La Rosa DF
        • Vigorita VJ
        • et al.
        A quantitative histologic comparison: ACL degeneration in the osteoarthritic knee.
        J Arthroplasty. 2003; 18: 687-692
        • Jones AC
        • Chuck AJ
        • Arie EA
        • et al.
        Diseases associated with calcium pyrophosphate deposition disease.
        Semin Arthritis Rheum. 1992; 22: 188-202
        • Jensen PS
        • Putman CE
        Current concept with respect to chondrocalcinosis and the pseudogout syndrome.
        AJR Am J Roentgenol. 1975; 125: 531-539
        • Chard MD
        • Cawston TE
        • Riley GP
        • et al.
        Rotator cuff degeneration and lateral epicondylitis-a comparative histological study.
        Ann Rheum Dis. 1994; 53: 30-34
        • Riley GP
        • Harrall RL
        • Constant CR
        • et al.
        Prevalence and possible pathological significance of calcium phosphate salt accumulation in tendon matrix degeneration.
        Ann Rheum Dis. 1996; 55: 109-115
        • Cheung HS
        • Story MT
        • McCarty DJ
        Mitogenic effects of hydroxyapatite and calcium pyrophosphate dihydrate crystals on cultured mammalian cells.
        Arthritis Rheum. 1984; 27: 668-674
        • Suan JC
        • Chhem RK
        • Gati JS
        • et al.
        4T MR of chondrocalcinosis in combination with 3D CT, radiography, and arthroscopy: a report of three cases.
        Skeletal Radiol. 2005; 34: 714-721