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Collision in the inferior olive: hypertrophic olivary degeneration complicated by radiation necrosis in brainstem primitive neuroendocrine tumor

  • Author Footnotes
    1 These authors contributed equally.
    Patricia Litkowski
    Footnotes
    1 These authors contributed equally.
    Affiliations
    Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
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  • Author Footnotes
    1 These authors contributed equally.
    Robert J. Young
    Correspondence
    Corresponding author. Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, MRI-1156, New York, NY 10065, USA. Tel.: +1 212 639 8196 (office); fax: +1 917 432 2345.
    Footnotes
    1 These authors contributed equally.
    Affiliations
    Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA

    Department of Brain Tumor Center, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
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  • Suzanne L. Wolden
    Affiliations
    Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA

    Department of Brain Tumor Center, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
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  • Mark M. Souweidane
    Affiliations
    Department of Neurosurgery, Memorial Sloan-Kettering Cancer Center, New York, NY, USA

    Department of Brain Tumor Center, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
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  • Sofia Haque
    Affiliations
    Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA

    Department of Brain Tumor Center, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
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  • Stephen W. Gilheeney
    Affiliations
    Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA

    Department of Brain Tumor Center, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
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  • Author Footnotes
    1 These authors contributed equally.
Published:November 07, 2011DOI:https://doi.org/10.1016/j.clinimag.2011.09.014

      Abstract

      Hypertrophic olivary degeneration (HOD) is caused by disruption of the triangle of Guillain and Mollaret. We describe a child with a primitive neuroendocrine tumor who developed an expansile nonenhancing lesion in the olive after surgery and radiation therapy. Diffusion tensor imaging and tractography showed disruption of the central tegmental tract consistent with HOD. Subsequent transient enhancement of the olive was consistent with early radiation injury. Knowledge of coexisting complications such as HOD and radiation injury is essential for proper management.

      Keywords

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      References

        • Kitajima M
        • Korogi Y
        • Shimomura O
        • et al.
        Hypertrophic olivary degeneration: MR imaging and pathologic findings.
        Radiology. 1994; 192: 539-543
        • Gautier JC
        • Blackwood W
        Enlargement of the inferior olivary nucleus in association with lesions of the central tegmental tract or dentate nucleus.
        Brain. 1961; 84: 341-361
        • Ogawa K
        • Mizutani T
        • Uehara K
        • et al.
        Pathological study of pseudohypertrophy of the inferior olivary nucleus.
        Neuropathology. 2010; 30: 15-23
        • Goyal M
        • Versnick E
        • Tuite P
        • et al.
        Hypertrophic olivary degeneration: metaanalysis of the temporal evolution of MR findings.
        AJNR Am J Neuroradiol. 2000; 21: 1073-1077
        • Goto N
        • Kaneko M
        Olivary enlargement: chronological and morphometric analyses.
        Acta Neuropathol. 1981; 54: 275-282
        • Jiang H
        • van Zijl PC
        • Kim J
        • et al.
        DtiStudio: resource program for diffusion tensor computation and fiber bundle tracking.
        Comput Methods Programs Biomed. 2006; 81: 106-116
        • Vaidhyanath R
        • Thomas A
        • Messios N
        Bilateral hypertrophic olivary degeneration following surgical resection of a posterior fossa epidermoid cyst.
        Br J Radiol. 2010; 83: e211-e215
        • Hornyak M
        • Osborn AG
        • Couldwell WT
        Hypertrophic olivary degeneration after surgical removal of cavernous malformations of the brain stem: report of four cases and review of the literature.
        Acta Neurochir (Wien). 2008; 150 ([discussion 156]): 149-156
        • Desai K
        • Young RJ
        • Golfinos J
        • et al.
        Hypertrophic Olivary Degeneration in a Patient Treated by Gamma Knife for Pontine Metastasis. Radiological Society of North America, Chicago2006
        • Mayo C
        • Yorke E
        • Merchant TE
        Radiation associated brainstem injury.
        Int J Radiat Oncol Biol Phys. 2010; 76: S36-S41
        • Shah R
        • Markert J
        • Bag AK
        • et al.
        Diffusion tensor imaging in hypertrophic olivary degeneration.
        AJNR Am J Neuroradiol. 2010; 31: 1729-1731
        • Dincer A
        • Ozyurt O
        • Kaya D
        • et al.
        Diffusion tensor imaging of Guillain–Mollaret triangle in patients with hypertrophic olivary degeneration.
        J Neuroimaging. 2011; 21: 145-151