Abstract
Purpose
Performance of proton magnetic resonance spectroscopy (H-MRS) and apparent diffusion
coefficient (ADC) values in the diagnosis of malignant thyroid nodules.
Method
In a retrospective study with malignant nodules of 14 patients, H-MRS and diffusion-weighted
MR imaging (DWI) were performed. Choline (Cho) peak, Cho/creatine (Cr) ratio, and
ADC values of malignant nodules were correlated with the five benign nodules and four
normal-appearing thyroid lobe parenchymata. The gold standard reference was fine needle
aspiration biopsy and histopathology.
Results
At echo time 40–144-ms acquisitions, average Cho/Cr ratio for the malignant nodules
was 2.95±1.54–5.30±2.38, cutoff values were >0.805 and >1.225, and ADC values were
0.06±0.02.
Conclusion
H-MRS acquisitions, DWI, and ADC mapping give diagnostic data about the nature of
the nodules.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Clinical ImagingAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Diffusion weighted images differentiate benign from malignant thyroid nodules.J Magn Reson Imaging. 2010; 31: 94-100
- Diffusion weighted MR imaging of thyroid nodules.Neuroradiology. 2009; 51: 193-198
- Role of apparent diffusion coefficient values in differentiation between malignant and benign solitary thyroid nodules.AJNR. 2008; 29: 563-568
- In vivo H-MR spectroscopy of thyroid carcinoma.EJR. 2005; 54: 112-117
- Can quantitative diffusion-weighted MR imaging differentiate benign from malignant cold thyroid nodules? Initial results in 25 patients.AJNR. 2009; 30: 417-422
- The pre-operative exclusion of thyroid carcinoma in multi-nodular goiter: dynamic contrast-enhanced magnetic resonance imaging versus ultrasonography-guided fine needle aspiration biopsy.Surgery. 2007; 142: 992-1002
- Qualitative and quantitative evaluation of solitary thyroid nodules with contrast-enhanced ultrasound: initial results.Eur Radiol. 2006; 16: 2234-2241
- Sonography of thyroid nodules: a classical pattern diagnostic approach.Ultrasound Q. 2005; 21: 157-165
- The use of fine-needle aspiration biopsy under ultrasound guidance to assess the risk of malignancy in patients with a multinodular goiter.Thyroid. 2000; 10: 235-241
- Utility of fine-needle aspiration for diagnosis of carcinoma associated with multinodular goiter.Clin Endocrinol. 2004; 61: 732-737
- MR imaging of the thyroid and parathyroid glands.Magn Reson Imaging Clin North Am. 2000; 8: 163-182
- Risk for malignancy of thyroid nodules as assessed by sonographic criteria: the need for biopsy.J Ultrasound Med. 2004; 23: 1455-1464
- Imaging of the thyroid: correlation between apparent diffusion coefficient and thyroid gland scintigraphy.J Magn Reson Imaging. 2003; 17: 163-169
- Diagnostic value of sonography, ultrasound-guided fine-needle aspiration cytology and diffusion-weighted MRI in the characterization of cold thyroid nodules.Eur J Radiol. 2010; 73: 538-544
- Magnetic resonance spectroscopy as a diagnostic modality for carcinoma thyroid.Eur J Radiol. 2007; 64: 414-418
- Proton-MR spectroscopy improves discrimination between tumour and pseudo-tumoral lesion in solid brain masses.AJNR. 2009; 30: 544-551
- Removal of the water resonance from H-1 Magnetic resonance spectra.in: McWhirter JG Mathematics in signal processing 3. Clarendon, Oxford, England1994: 175-195
- New sonographic criteria for recommending fine-needle aspiration biopsy of nonpalpable solid nodules of the thyroid.AJR. 2002; 38: 1105-1129
- False-negative fine-needle aspiration cytology results delay treatment and adversely affect outcome in patients with thyroid carcinoma.Thyroid. 2004; 14: 207-215
- H-MR spectroscopy of inflammation, infection and ischemia of the brain.Eur J Radiol. 2008; 67: 250-257
- H-MR spectroscopy indicates severity markers in temporal lobe epilepsy: correlations between metabolic alterations, seizures and epileptic discharges in EEG.Epilepsia. 2007; 48: 263-269
- Multi-voxel MR Spectroscopic imaging of the brain: utility in clinical setting-initial results.Eur J Radiol. 2005; 55: 401-408
- Diagnosis of follicular thyroid lesions by proton magnetic resonance on fine needle biopsy.J Clin Endocrinol Metab. 1995; 80: 1306-1311
- Proton magnetic resonance and human thyroid neoplasia1: discrimination between benign and malignant neoplasms.Am J Med. 1994; 96: 383-388
- Proton magnetic resonance and human thyroid neoplasia. Potential avoidance of surgery for benign follicular neoplasia.World J Surg. 1994; 18: 512-516
- Head and neck lesions: characterization with diffusion-weighted echo-planar MR imaging.Radiology. 2001; 22: 621-630
- MR imaging of intra-voxel incoherent motions; application to diffusion and perfusion in neurologic disorders.Radiology. 1988; 168: 497-505
- Diffusion weighted MRI in the body: applications and challenges in oncology.AJR. 2007; 188: 1622-1635
- Differentiation of benign and malignant pathology in the head and neck using 3T apparent diffusion coefficient values: early experience.AJNR. 2008; 29: 40-44
- Comparison of 1.5T and 3T 1H-MR spectroscopy for human brain tumours.Korean J Radiol. 2006; 7: 156-161
Article info
Publication history
Published online: January 09, 2012
Accepted:
September 27,
2011
Received in revised form:
September 22,
2011
Received:
July 10,
2011
Footnotes
☆All authors stated no conflicts of interest.
Identification
Copyright
© 2012 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
