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The role of proton MR spectroscopy and apparent diffusion coefficient values in the diagnosis of malignant thyroid nodules: preliminary results

      Abstract

      Purpose

      Performance of proton magnetic resonance spectroscopy (H-MRS) and apparent diffusion coefficient (ADC) values in the diagnosis of malignant thyroid nodules.

      Method

      In a retrospective study with malignant nodules of 14 patients, H-MRS and diffusion-weighted MR imaging (DWI) were performed. Choline (Cho) peak, Cho/creatine (Cr) ratio, and ADC values of malignant nodules were correlated with the five benign nodules and four normal-appearing thyroid lobe parenchymata. The gold standard reference was fine needle aspiration biopsy and histopathology.

      Results

      At echo time 40–144-ms acquisitions, average Cho/Cr ratio for the malignant nodules was 2.95±1.54–5.30±2.38, cutoff values were >0.805 and >1.225, and ADC values were 0.06±0.02.

      Conclusion

      H-MRS acquisitions, DWI, and ADC mapping give diagnostic data about the nature of the nodules.

      Keywords

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