Abstract
Heterotopia is a subgroup of migration abnormalities, recognized by arrest of radial
migration of neuroblasts. Being a well-known cause for developmental delay, mental
retardation, and epilepsy, association of heterotopia with some other conditions has
also been proposed. There are several case reports regarding the concurrence of heterotopia
and encephalocele; however, no such association has been reported with cervical meningocele.
Herein, we present the first case of periventricular nodular heterotopia associated
with cervical meningocele. Our case further emphasizes the role of brain MRI in the
evaluation of those with neural tube defects. Recognition of possible associated heterotopia
is important for planning proper treatment and genetic counseling.
Keywords
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References
- Disorders of neural migration.Can J Neurol Sci. 1987; 14: 1-16
- Malformations of the brain.J Neuropathol Exp Neurol. 1996; 55: 133-143
- Gray matter heterotopias: MR characteristics and correlation with developmental and neurologic manifestations.Radiology. 1992; 182: 493-499
- Periventricular and subcortical nodular heterotopia. A study of 33 patients.Brain. 1995; 118: 1273-1287
- Pediatric Neuroimaging. 2nd ed. Raven Press, New York1995: 177-275
- Subependymal nodular heterotopia in patients with encephalocele.Eur J Paediatr Neurol. 1999; 3: 59-63
- Anterior encephaloceles: a study of 92 cases.Pediatr Neurosurg. 2002 Mar; 36: 113-118
- Anterior encephalocele associated with subependymal nodular heterotopia, cortical dysplasia and epilepsy: case report and review of the literature.Eur J Paediatr Neurol. 2006; 10 (Epub 2006 Oct 10): 227-229
- Cervical meningocele in association with spinal abnormalities.Childs Nerv Syst. 2004; 20 (Epub 2003 Nov 13): 357-361
- The spinal cord lesion in spina bifida cystica.Lancet. 1956; 271: 171-174
- Dysraphic lesions of the cervical spinal cord.Neurosurg Clin N Am. 1995; 6: 367-376
- Cervical myelocystocele with Chiari II malformation: magnetic resonance imaging and surgical treatment.Surg Neurol. 1998; 49: 269-273
- Congenital abnormalities. Syllabus for the Categorical Course on MR.American College of Radiology, Reston, VA1985
- Periventricular nodular heterotopia and epilepsy.Intern Med J. 2008; 38: 675-676
- Gray matter heterotopias.Neurology. 2000; 55: 1603-1608
- Cervical meningocele and associated spinal anomalies.Child's Nerv Syst. 1987; 3: 165-169
Article info
Publication history
Published online: July 09, 2010
Accepted:
April 15,
2010
Received:
March 20,
2010
Identification
Copyright
© 2011 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
