Abstract
This study aimed to investigate the relationship between the expression of the molecular
markers, extracellular matrix metalloproteinase inducer (EMMPRIN), galectin-3, and
microvessel density (MVD) with MRI invasive features in invasive and noninvasive pituitary
adenomas. MRI was performed preoperatively in 34 patients with histologically verified
pituitary adenomas. The expression of EMMPRIN, galectin-3, and MVD was determined
by using immunohistochemical techniques on excised surgical specimen from all patients.
Correlative analyses between invasive MRI features and expression of EMMPRIN, galectin-3,
and MVD were determined between invasive and noninvasive pituitary adenomas. Among
MRI invasive features, adenoma crossing the lateral line (LL) of the internal carotid
artery (ICA), percentage of intracavernous ICA encasement by the tumor over 50%, sphenoidal
sinus invasion, irregular tumor shape, and bilateral ICA asymmetry correlated with
increased expression of EMMPRIN and galectin-3 (P<.05), but tumor cystic necrosis and tumor apoplexy did not correlate with EMMPRIN
and galectin-3 expression (P>.05). The invasive MRI features did not correlate with MVD expression. This study
demonstrated that EMMPRIN and galectin-3 were associated with aggressiveness and invasion
by pituitary adenoma. Furthermore, EMMPRIN and galectin-3 were two potential molecular
markers for assessing the invasive potential of pituitary adenoma and may provide
useful targets for molecular therapeutic strategy against invasive pituitary adenomas.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Clinical ImagingAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Magnetic resonance imaging and biological markers in pituitary adenomas with invasion of the cavernous sinus space.J Neurooncol. 2005; 74: 71-76
- Pituitary adenomas with invasion of the cavernous sinus space: a magnetic resonance imaging classification compared with surgical findings.Neurosurgery. 1993; 33: 610-617
- Cavernous sinus invasion by pituitary adenoma: MR imaging.Radiology. 2000; 215: 463-469
- MR imaging features of thyrotropin-secreting pituitary adenomas at initial presentation.AJR Am J Roentgenol. 2003; 181: 577-582
- Proliferation, vascular endothelial growth factor expression and cavernous sinus invasion in growth hormone secreting pituitary adenomas.Acta Neurochir (Wien). 2000; 142: 1345-1351
- Tumor angiogenesis correlates with metastasis in invasive prostate carcinoma.Am J Pathol. 1993; 143: 401-409
- Application of three-tesla magnetic resonance imaging for diagnosis and surgery of sellar lesions.J Neurosurg. 2004; 100: 278-286
- Expressions of CD147 and matrix metalloproteinase-2 in breast cancer and their correlations to prognosis.Ai Zheng. 2005; 24: 874-879
- Stimulation of matrix metalloproteinase production by recombinant extracellular matrix metalloproteinase inducer from transfected Chinese hamster ovary cells.J Biol Chem. 1997; 272: 24-27
- Emmprin (basigin/CD147): matrix metalloproteinase modulator and multifunctional cell recognition molecule that plays a critical role in cancer progression.Pathol Int. 2006; 56: 359-367
- Glioma cell extracellular matrix metalloproteinase inducer (EMMPRIN) (CD147) stimulates production of membrane-type matrix metalloproteinases and activated gelatinase A in co-cultures with brain-derived fibroblasts.Cancer Lett. 2000; 157: 177-184
- A role for CD147 in thymic development.J Immunol. 2002; 168: 4946-4950
- The study on expression and relationship between matrix metalloproteinase-2 and CD147 in invasive pituitary adenomas.J Nerv Ment Dis. 2005; 31: 168-171
- Galectin-3 expression in functioning and silent ACTH-producing adenomas.Endocr Pathol. 2005; 16: 107-114
- Differential expression of galectin-3 in pituitary tumors.Cancer Res. 2003; 63: 2251-2255
- The role of apoptosis in pituitary adenomas in the field of conventionally used therapeutic approaches.Ann N Y Acad Sci. 2003; 1010: 520-524
- Angiogenesis in pituitary adenomas and the normal pituitary gland.J Clin Endocrinol Metab. 2000; 85: 1159-1162
- Microvessel density in pituitary adenomas and carcinomas.Virchows Arch. 2001; 438: 596-602
- Vascular networks and endothelial cells in the rat experimental pituitary glands and in the human pituitary adenomas.Microsc Res Tech. 2003; 60: 231-235
- Evaluation of magnetic resonance imaging criteria for cavernous sinus invasion in patients with pituitary adenomas: logistic regression analysis and correlation with surgical findings.Surg Neurol. 2006; 65: 130-135
- Inhibition of human cancer cell growth and metastasis in nude mice by oral intake of modified citrus pectin.J Natl Cancer Inst. 2002; 94: 1854-1856
Article info
Publication history
Published online: July 21, 2010
Accepted:
April 15,
2010
Received:
March 25,
2010
Identification
Copyright
© 2011 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
