Abstract
There are several artifacts encountered in positron emission tomography/computed tomographic
(PET/CT) imaging, including attenuation correction (AC) artifacts associated with
using CT for AC. Several artifacts can mimic a 2-deoxy-2-[18F] fluoro-d-glucose (FDG) avid malignant lesions and therefore recognition of these artifacts
is clinically relevant. Our goal was to identify and characterize these artifacts
and also discuss some protocol variables that may affect image quality in PET/CT.
Keywords
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References
- Normal physiological and benign pathological variants of 18-fluoro-2-deoxyglucose positron-emission tomography scanning: potential for error in interpretation.Semin Nucl Med. 1996; 26: 308-314
- Photopenic defects in FDG PET scanning.in: AUR20022002
- CT-based attenuation correction for PET-CT scanners.in: von Schultess G Clinical PET, PET-CT and SPECT/CT: combined anatomic-molecular imaging. Williams and Wilkins, Lippincott2003: 46-58
- Role of attenuation correction for fluorine-18 fluorodeoxyglucose positron emission tomography in the primary staging of malignant lymphoma.Eur J Nucl Med. 1999; 26: 31-38
- Attenuation correction for a combined 3D PET/CT scanner.Med Phys. 1998; 25: 2046-2053
- PET attenuation coefficients from CT images: experimental evaluation of the transformation of CT into PET 511-keV attenuation coefficients.Eur J Nucl Med Mol Imaging. 2002; 29: 922-927
- Impact of patient weight and emission scan duration on PET/CT image quality and lesion detectability.J Nucl Med. 2004; 45: 797-801
- Focal tracer uptake: a potential artifact in contrast-enhanced dual-modality PET/CT scans.J Nucl Med. 2002; 43: 1339-1342
- Acquisition protocol considerations for combined PET/CT imaging.J Nucl Med. 2004; 45: 25S-35S
- Application of intravenous contrast in PET/CT: does it really introduce significant attenuation correction error?.J Nucl Med. 2005; 46: 283-291
- Optimized intravenous contrast administration for diagnostic whole-body 18F-FDG PET/CT.J Nucl Med. 2005; 46: 429-435
- Central line injection artifact simulating paratracheal adenopathy on FDG PET imaging.Clin Nucl Med. 2004; 29: 735-737
- Head and neck imaging with PET and PET/CT: artefacts from dental metallic implants.Eur J Nucl Med Mol Imaging. 2002; 29: 367-370
- Combined PET-CT in the head and neck: part 1. Physiologic, altered physiologic, and artifactual FDG uptake.Radiographics. 2005; 25: 897-912
- Radiation exposure of patients undergoing whole-body dual-modality 18F-FDG PET/CT examinations.J Nucl Med. 2005; 46: 608-613
- Positron emission tomography/computed tomography — imaging protocols, artifacts, and pitfalls.Mol Imaging Biol. 2004; 6: 188-199
- Dual-modality PET/CT scanning with negative oral contrast agent to avoid artifacts: introduction and evaluation.Radiology. 2004; 230: 879-885
- Correction for oral contrast artifacts in CT attenuation-corrected PET images obtained by combined PET/CT.J Nucl Med. 2003; 44: 1940-1944
- Applications of positron emission tomography/computed tomography image fusion in clinical positron emission tomography — clinical use, interpretation methods, diagnostic improvements.Semin Nucl Med. 2003; 33: 228-237
- CT-based attenuation correction in the calculation of semi-quantitative indices of [18F]FDG uptake in PET.Eur J Nucl Med Mol Imaging. 2003; 30: 344-353
- Initial experience with oral contrast in PET/CT: phantom and clinical studies.J Nucl Med. 2003; 44: 412-416
- Application of oral contrast media in coregistered positron emission tomography-CT.AJR Am J Roentgenol. 2002; 179: 477-481
- Clinical PET/CT scanning using oral CT contrast agents.J Nucl Med. 2002; 45: 57
- Impact of metallic dental implants on CT-based attenuation correction in a combined PET/CT scanner.Eur Radiol. 2003; 13: 724-728
- Artifacts at PET and PET/CT caused by metallic hip prosthetic material.Radiology. 2003; 226: 577-584
- Artifactual 2-deoxy-2-[(18)F]fluoro-d-glucose localization surrounding metallic objects in a PET/CT scanner using CT-based attenuation correction.Mol Imaging Biol. 2003; 5: 20-22
- Clinical evaluation of a breathing protocol for PET/CT.Eur Radiol. 2004; 14: 1118-1123
- PET/CT of the abdomen: optimizing the patient breathing pattern.Eur Radiol. 2003; 13: 734-739
- Dual-modality PET/CT imaging: the effect of respiratory motion on combined image quality in clinical oncology.Eur J Nucl Med Mol Imaging. 2003; 30: 588-596
- Respiratory motion artifacts on PET emission images obtained using CT attenuation correction on PET-CT.Eur J Nucl Med Mol Imaging. 2003; 30: 603-606
- Single-detector helical CT in PET-CT: assessment of image quality.AJR Am J Roentgenol. 2004; 182: 1571-1577
- Clinically significant inaccurate localization of lesions with PET/CT: frequency in 300 patients.J Nucl Med. 2003; 44: 240-243
- Respiratory gating with a 16-slice LSO PET-CT scanner.J Nucl Med. 2004; 45 (abstract): 165
- Potential false-positive FDG PET imaging caused by subcutaneous radiotracer infiltration.Clin Nucl Med. 2003; 28: 786-788
Article info
Publication history
Published online: May 26, 2010
Accepted:
February 21,
2010
Received:
December 10,
2009
Footnotes
☆Work for this article was performed at: Hillman Cancer Center, UPMC Department of Radiology.
☆☆Funding received: NIH Grant Number R21 EB002622, National Cancer Institute Grant Number P30 CA47904.
Identification
Copyright
© 2011 Elsevier Inc. Published by Elsevier Inc. All rights reserved.