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Dedifferentiated liposarcoma of retroperitoneum: spectrum of imaging findings in 15 patients

      Abstract

      Background

      Dedifferentiated liposarcoma is a high-grade nonlipogenic sarcoma that arises in the background of a preexisting well-differentiated liposarcoma. The purpose of this work is to evaluate the spectrum of radiologic appearance of retroperitoneal dedifferentiated liposarcoma with clinicopathologic features.

      Methods

      Radiologic images and clinical histories of 15 patients with histologically verified retroperitoneal dedifferentiated liposarcoma were retrospectively studied. Patients included 11 men and 4 women, with mean age of 55.8 years (range, 36–74 years), and they underwent computed tomography (CT) (n=15) and magnetic resonance imaging (MRI) (n=5).

      Results

      The mean size of the tumor was 22.6 cm with a range of 9.5–38 cm. Both CT and MRI showed well-circumscribed, large round, or lobulated retroperitoneal mass. The appearance of the tumor was classified as follows: Category I, nonfatty component within predominant fatty mass (n=5); Category II, focal fatty component within large nonfatty mass (n=6); Category III, well-defined fatty mass and well-defined nonfatty mass (n=1); Category IV, two masses with predominantly nonfatty component (n=3).

      Conclusion

      Retroperitoneal dedifferentiated liposarcomas present various spectra of imaging findings. While Categories I and III may suggest dedifferentiated liposarcoma, Categories II and IV may appear as other types of liposarcoma or other malignant retroperitoneal tumor.

      Keywords

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      References

        • Fletcher CDM
        • Unni KK
        • Mertens F
        Pathology and genetics of tumours of soft tissue and bone.
        IARC Press, Lyon2002
        • Murphey MD
        • Arcara LK
        • Fanburg-Smith J
        From the archives of the AFIP: imaging of musculoskeletal liposarcoma with radiologic–pathologic correlation.
        Radiographics. 2005; 25: 1371-1395
        • Henricks WH
        • Chu YC
        • Goldblum JR
        • Weiss SW
        Dedifferentiated liposarcoma: a clinicopathological analysis of 155 cases with a proposal for an expanded definition of dedifferentiation.
        Am J Surg Pathol. 1997; 21: 271-281
        • Tateishi U
        • Hasegawa T
        • Beppu Y
        • Satake M
        • Moriyama N.
        Primary dedifferentiated liposarcoma of the retroperitoneum. Prognostic significance of computed tomography and magnetic resonance imaging features.
        J Comput Assist Tomogr. 2003; 27: 799-804
        • Toshiyasu T
        • Ehara S
        • Yamaguchi T
        • Nishida J
        • Shiraishi H
        Dedifferentiated liposarcoma of the retroperitoneum with osteosarcomatous component: report of two cases.
        Clin Imaging. 2009; 33: 70-74
        • Kransdorf MJ
        • Meis JM
        • Jelinek JS
        Dedifferentiated liposarcoma of the extremities: imaging findings in four patients.
        AJR Am J Roentgenol. 1993; 161: 127-130
        • Song T
        • Shen J
        • Liang BL
        • Mai WW
        • Li Y
        • Guo HC.
        Retroperitoneal liposarcoma: MR characteristics and pathological correlative analysis.
        Abdom Imaging. 2007; 32: 668-674
        • Weiss SW
        • Rao VK.
        Well-differentiated liposarcoma (atypical lipoma) of deep soft tissue of the extremities, retroperitoneum, and miscellaneous sites. A follow-up study of 92 cases with analysis of the incidence of “dedifferentiation”.
        Am J Surg Pathol. 1992; 16: 1051-1058
        • Binh MB
        • Guillou L
        • Hostein I
        • Chateau MC
        • Collin F
        • Aurias A
        • et al.
        Dedifferentiated liposarcomas with divergent myosarcomatous differentiation developed in the internal trunk: a study of 27 cases and comparison to conventional dedifferentiated liposarcomas and leiomyosarcomas.
        Am J Surg Pathol. 2007; 31: 1557-1566
        • Weiss SW
        • Goldblum JR
        • Enzinger FM
        Enzinger and Weiss's soft tissue tumors.
        4th ed. Mosby, St. Louis2001