Efficacy of dual-source CT coronary angiography in evaluating coronary stenosis: initial experience



      To retrospectively assess the diagnostic efficacy of dual-source CT angiography (DSCTA) in detecting and grading coronary stenosis.


      Institutional review board approval and informed consent were obtained. One hundred ten patients were performed with both DSCTA and conventional coronary angiography (CCA) without heart rate or rhythm control in 1 week. Regarding CCA as the gold standard, the assessable rate of coronary arteries and diagnostic value of coronary stenosis using DSCTA were analyzed, respectively. The intermodality agreement between DSCTA and CCA in grading coronary stenosis was assessed using κ test. The value of DSCTA in diagnosing >50% coronary stenoses was also assessed.


      The overall assessable rate of DSCTA was 98.6% in detecting coronary arteries; there was no significant difference between assessable rates from different groups of heart rate (χ2=0.45, P > .05). The efficacy of DSCTA was of 97.9% sensitivity, 97.3% specificity, 90.4% positive predictive value, and 99.4% negative predictive value for coronary stenosis; and 94.7% sensitivity, 96.8% specificity, 83.7% positive predictive value, and 99% negative predictive value for >50% stenoses. The intermodality agreement in diagnosing coronary stenosis was satisfactory (k=0.87, u=58.46, P<.01).


      As an effective noninvasive diagnostic tool, DSCTA yields a promising accuracy and reliability in assessing coronary stenosis. It may be recommended as a valuable screening tool for coronary artery disease, and a potential challenge to CCA as well.


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        • Achenbach S
        • Ropers D
        • Kuettner A
        • et al.
        Contrast-enhanced coronary artery visualization by dual-source computed tomography — initial experience.
        Eur J Radiol. 2006; 57: 331-335
        • Johnson TR
        • Nikolaou K
        • Wintersperger BJ
        • et al.
        Dual-source CT cardiac imaging: initial experience.
        Eur Radiol. 2006; 16: 1409-1415
        • Bashore TM
        • Bates ER
        • Berger PB
        • et al.
        American College of Cardiology/Society for Cardiac Angiography and Interventions Clinical Expert Consensus Document on cardiac catheterization laboratory standards: a report of the American College of Cardiology Task Force on Clinical Expert Consensus Documents.
        J Am Coll Cardiol. 2001; 37: 2170-2214
        • Austen W
        • Edward J
        • Frye R
        • et al.
        A reporting system on patients evaluated for coronary artery disease: report of the Ad-hoc Committee for Grading of Coronary Artery Disease, Council on Cardiovascular surgery, American Heart Association.
        Circulation. 1975; 51: 5-50
        • Achenbach S
        • Giesler T
        • Roper T
        • et al.
        Detection of coronary artery stenoses by contrast enhanced retrospectively electrocardiographically-gated multislice spiral computed tomography.
        Circulation. 2001; 103: 2535-2538
        • Kopp F
        • Schroeder S
        • Kuettner A
        • et al.
        Non-invasive coronary angiography with high resolution multidetector-row computed tomography.
        Eur Heart J. 2002; 23: 1714-1725
        • Ropers D
        • Baum U
        • Pohle K
        • et al.
        Detection of coronary artery stenoses with thin slice multi-detector row spiral computed tomography and multiplanar reconstruction.
        Circulation. 2003; 107: 664-666
        • Martuscelli E
        • Romagnoli A
        • Eliseo A
        • et al.
        Accuracy of thin-slice computed tomography in the detection of coronary stenoses.
        Eur Heart J. 2004; 25: 1043-1048
        • Leschka S
        • Wildermuth S
        • Boehm T
        • et al.
        Noninvasive coronary angiography with 64-section CT: effect of average heart rate and heart rate variability on image quality.
        Radiology. 2006; 241: 378-385
        • Ferencik M
        • Nomura CH
        • Maurovich-Horvat P
        • et al.
        Quantitative parameters of image quality in 64-slice computed tomography angiography of the coronary arteries.
        Eur J Radiol. 2006; 57: 373-379
        • Wintersperger BJ
        • Nikolaou K
        • von Ziegler F
        • et al.
        Image quality, motion artifacts, and reconstruction timing of 64-slice coronary computed tomography angiography with 0.33-second rotation speed.
        Invest Radiol. 2006; 41: 436-442
        • Leschka S
        • Alkadhi H
        • Plass A
        • et al.
        Accuracy of MSCT coronary angiography with 64-slice technology: first experience.
        Eur Heart J. 2005; 26: 1482-1487
        • Mollet NR
        • Cademartiri F
        • Mieghem C
        • et al.
        High-resolution spiral computed tomography coronary angiography in patients referred for diagnostic conventional coronary angiography.
        Circulation. 2005; 112: 2318-2323
        • Scheffel H
        • Alkadhi H
        • Plass A
        • et al.
        Accuracy of dual-source ct coronary angiography: first experience in a high pre-test probability population without heart rate control.
        Eur Radiol. 2006; 16: 2739-2747
        • Matt D
        • Scheffel H
        • Leschka S
        • et al.
        Dual-source CT coronary angiography: image quality, mean heart rate, and heart rate variability.
        AJR Am J Roentgenol. 2007; 189: 567-573
        • Pansini V
        • Remy-Jardin M
        • Tacelli N
        • et al.
        Screening for coronary artery disease in respiratory patients: comparison of single-and dual-source CT in patients with a heart rate above 70 bpm.
        Eur Radiol. 2008; 18: 2108-2119
        • Reimann AJ
        • Rinck D
        • Birinci-Aydogan A
        • et al.
        Dual-Source Computed Tomography: Advances of Imporal Resolution in Coronary Plaque Imaging.
        Invest Radiol. 2007; 42: 196-203
        • Lu G-M
        • Zhang L-J
        • Guo H
        • et al.
        Comparison of myocardial bridging by dual-Source CT with conventional coronary angiography.
        Circulation. 2008; 72: 1079-1085
        • Johnson TRC
        • Nikolaou K
        • Busch S
        • et al.
        Diagnostic Accuracy of Dual-Source Computed Tomography in the Diagnosis of Coronary Artery Disease.
        Invest Radiol. 2007; 42: 684-691
        • Boll DT
        • Hoffmann MH
        • Bossert AS
        • et al.
        New frontiers in coronary plaque imaging and characterization: polychromatic dual energy multidetector CT with histopathologic correlation.
        Radiology. 2005; : SSD08-SSD09