Research Article| Volume 34, ISSUE 6, P432-440, November 2010

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Diffusion-weighted MRI with parallel imaging technique: apparent diffusion coefficient determination in normal kidneys and in nonmalignant renal diseases

Published:November 23, 2009DOI:


      The purpose of the study was to assess the capability and the reliability of apparent diffusion coefficient (ADC) measurements in the evaluation of different benign renal abnormalities. Twenty-five healthy volunteers and 31 patients, divided into seven different groups (A–G) according to pathology, underwent diffusion-weighted magnetic resonance imaging (DW MRI) of the kidneys using 1.5-T system. DW images were obtained in the axial plane with a spin-echo echo planar imaging single-shot sequence with three b values (0, 300, and 600 s/mm2). Before acquisition of DW sequences, we performed in each patient a morphological study of the kidneys. ADC was 2.40±0.20×10−3 mm2 s−1 in volunteers. A significant difference was found between Groups A (cysts=3.39±0.51×10−3 mm2 s−1) and B (acute/chronic renal failure=1.38±0.40×10−3 mm2 s−1) and between Groups A and C (chronic pyelonephritis=1.53±0.21×10−3 mm2 s−1) (P<.05). An important difference was also observed among Group D (hydronephrosis=4.82±0.35×10−3 mm2 s−1) and Groups A, B, and C (P<.05), whereas no differences were found between Groups B and C (P>.05). A considerable correlation between glomerular filtration rate and ADC was found (P=.04). In conclusion, significant differences were detected among different patient groups, and this suggests that ADC measurements can be useful in differentiating normal renal parenchyma from most commonly encountered nonmalignant renal lesions.


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