Abstract
Aim
Cerebral hemodynamic derangement is well known in patients with fulminant hepatic
failure. The advent of transcranial Doppler sonography (TCD) enabled noninvasive observation
of cerebral hemodynamics. To evaluate its clinical usefulness, we examined longitudinal
cerebral hemodynamic parameters in patients with fulminant hepatic failure and severe
acute hepatitis.
Methods
The six subjects were four patients with fulminant hepatic failure, one with severe
acute hepatitis and one with severe acute exacerbation on chronic hepatitis. The pulsatility
indices of the right middle cerebral artery were used as parameters of cerebral hemodynamics.
Results
The pulsatility indices of the two patients with a deteriorating course had elevated
to >1.00, whereas those of the two patients undergoing recovery were within normal
limits, as well as of the patients with acute hepatitis or acute exacerbation on chronic
hepatitis.
Conclusion
Cerebral pulsatility measured by TCD may be a real-time and useful tool to assess
and monitor patients with fulminant hepatic failure.
Keywords
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Article info
Publication history
Published online: November 13, 2009
Accepted:
September 10,
2009
Received:
August 28,
2009
Identification
Copyright
© 2010 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
