Abstract
When the anomalous origin of coronary arteries (AOCA) is suspected in children (especially
athletes), due to signs and symptoms of myocardial ischemia or on the basis of echocardiographic
assessment, three-dimensional coronary magnetic resonance angiography (3D-CMRA) can
be proposed for the fine morphological evaluation of coronary branches anatomy and
course.
We tested the diagnostic potential of CMRA angiography in a prospective study on AOCA
in young patients. Between July 2005 and June 2008, 15 patients aged 6–29 years (mean
age, 13.5 years±5.6 S.D.; median, 14) with clinical and echocardiographic suspicion
of AOCA underwent CMRA (1.5 T), 3D whole-heart, free-breathing technique, without
the use of contrast medium and β-blockers, with a mean examination time of 30 min.
We acquired a second scan of all patients to ameliorate the quality of the acquisition
and to improve our experience.
AOCA was confirmed by 3D-CMRA in 8 out of 15 cases (53%) and three different anatomical
variants were demonstrated, that is, ectopic origin of the left circumflex artery
arising from the right coronary artery with retro-aortic course in four cases, single
coronary artery arising from the right sinus of Valsalva with interarterial course
in one case, ectopic right coronary artery arising from the left sinus of Valsalva
with interarterial course in one case; in two patients without anomalies of origin
of the coronary arteries, elongated LMCA with angulation of the proximal segment of
the left circumflex artery was present.
When AOCA is suspected particularly in children (especially athletes), CMRA without
the use of contrast medium is an effective diagnostic technique, which is useful to
clarify the spatial position of the anomalous course of the main coronary branches
in order to suggest the most convenient management of the disease. CMRA does not need
contrast medium, needles, and β-blockers; is repeatable in the same examination without
the exposure to X-rays; allows a parent to stay near the child; and needs low collaboration
in low-stress conditions.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Clinical ImagingAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Coronary anomalies. Incidence, patophysiology and clinical relevance.Circulation. 2002; 105: 2449-2454
- Congenital coronary artery fistulas in adults: concomitant pathologies and treatment.Int J Cardiovasc Imaging. 2008; 24: 349-355
- Coronary artery anomalies.Tech Vasc Interv Radiol. 2006; 9: 210-217
- Coronary artery anomalies. A review of more than 10,000 patients from the Clayton Cardiovascular Laboratories.Tex Heart Inst J. 1988; 15: 166-173
- Anomalous origin of coronary arteries and risk of sudden death: a study based on an autopsy population of congenital heart disease.Hum Pathol. 1998; 29: 689-695
- Coronary artery anomalies—current clinical issues. Definitions, classification, incidence, clinical relevance and treatment guidelines.Tex Heart Inst J. 2002; 29: 271-278
- Three-dimensional respiratory-gated MR angiography of coronary arteries: comparison with conventional coronary angiography.AJR Am J Roentgenol. 1996; 166: 1399-1404
- Identification of anomalous coronary arteries and their anatomic course by magnetic resonance coronary angiography.Circulation. 1995; 92: 3158-3162
- Coronary artery anomalies: assessment with free-breathing three-dimensional coronary MR angiography.Radiology. 2003; 227: 201-208
- Detection and assessment of coronary artery anomalies by three-dimensional magnetic resonance coronary angiography.Int J Cardiol. 2005; 103: 317-322
- Cardiovascular magnetic resonance of anomalous coronary arteries.Coron Artery Dis. 2005; 16: 355-364
- Coronary magnetic resonance angiography for the detection of coronary stenoses.N Engl J Med. 2001; 345: 1863-1869
- Detection, visualization and evaluation of anomalous coronary anatomy on 16-slice multidetector-row CT.Eur Radiol. 2004; 14: 2163-2171
- Multislice CT imaging of anomalous coronary arteries.Eur Radiol. 2004; 14: 2181
- Visualization of coronary artery anomalies and their anatomic course by contrast-enhanced electron-beam coronary angiography.Am J Cardiol. 2001; 87: 193-197
- Congenital coronary anomalies in adults: comparison of anatomic course visualization by catheter angiography and electron beam CT.Catheter Cardiovasc Interv. 2005; 66: 34-42
- Imaging of congenital coronary anomalies with multislice computed tomography.Mayo Clin Proc. 2004; 79: 1017-1023
- Congenital anomalies of the coronary arteries: imaging with contrast enhanced, multidetector computer tomography.Eur Radiol. 2005; 15: 1110-1121
- Detection of anomalous origin of the coronary artery by means of multislice computed tomography.Circ J. 2005; 69: 320-324
- Anomalous coronary arteries in adults: depiction at multi-detector row CT angiography.Radiology. 2005; 235: 812-818
- Diagnosis of anomalous coronary arteries in 64-MDCT.Chin J Radiol. 2007; 32: 111-119
- Coronary artery anomalies: incidence, pathophysiology, clinical relevance and role of diagnostic imaging.Radiol Med (Torino). 2006; 111 (Epub 2006 Apr 11. Review. English, Italian): 376-391
- Multi-slice computed tomography and the detection of anomalies of coronary arteries.J Cardiovasc Med (Hagerstown). 2008 Feb; 9: 187-194
- Major variations in anatomical origin of the coronary arteries: angiographic observations in 4.250 patients without associated congenital heart disease.Catheter Cardiovasc Diagn. 1975; 1: 157-169
- Coronary artery anomalies in 126.595 patients undergoing coronary arteriography.Catheter Cardiovasc Diagn. 1990; 21: 28-40
- Primary congenital anomalies of the coronary arteries: a coronary arteriographic study.Int J Cardiol. 2000; 74: 39-46
- Coronary anomalies: incidence, pathophysiology and clinical relevance.Circulation. 2002; 105: 2449-2454
- Prevalence of anatomical variants and coronary anomalies in 543 consecutive patients studied with 64-slice CT coronary angiography.Eur Radiol. 2008; 18: 781-791
- Anomalous coronary arteries: a multicenter pediatric autopsy study.Pediatr Pathol. 1994; 14: 287-300
- Congenital coronary artery anomalies as an important cause of sudden death in young.Cardiol Rev. 2001; 9: 312-317
- Clinical profile of congenital coronary artery anomalies with origin from the wrong aortic sinus leading to sudden death in young competitive athletes.J Am Coll Cardiol. 2000; 35: 1493-1501
- Sudden death in young competitive athletes.J Am Coll Cardiol. 2000; 35: 1493-1501
- Cardiovascular pre-participation screening of young competitive athletes for prevention of sudden death: proposal for a common European protocol.Eur Heart J. 2005; 26: 516-524
- Symptoms preceding sudden cardiac death in the young are common but often misinterpreted.Scand Cardiovasc J. 2005; 39: 143-149
- Pre-participation screening of young competitive athletes for prevention of sudden cardiac death.J Am Coll Cardiol. 2008; 52: 1981-1989
- Preparticipation screening of competitive athletes. Seeking simple solutions to a complex problem.Circulation. 2009; 119: 1072-1074
- Complementary role of transoesophageal echocardiography to coronary angiography in the assessment of coronary artery anomalies.Br Heart J. 1993; 70: 70-74
- Major coronary artery anomalies in a pediatric population: incidence and clinical importance.J Am Coll Cardiol. 2001; 37: 593-597
- Estimating risk of cancer associated with radiation exposure from 64-slice computed tomography coronary angiography.JAMA. 2007; 298: 317-323
Article info
Publication history
Published online: December 03, 2009
Accepted:
August 24,
2009
Received:
July 22,
2009
Identification
Copyright
© 2010 Elsevier Inc. Published by Elsevier Inc. All rights reserved.