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Diffusion-weighted MRI evaluation of breast cancer extension

      Abstract

      Aim

      To investigate the feasibility of using diffusion-weighted MR imaging (DWI) to accurately measure breast cancer extension.

      Materials and Methods

      The extensions of 59 breast lesions were investigated on DW images and apparent diffusion coefficient (ADC) maps and compared to the pathological exams.

      Results

      Three groups were observed: accurate, overdiagnosis, and false negative. There were no significant differences seen in accurate or false-negative group when b was 500 and 1000 s/mm2 when two lesions in the overdiagnosis group at both b values.

      Conclusion

      DWI and the ADC value have potential for evaluating cancer extension.

      Keywords

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      References

        • Schelfout K
        • Van Goethem M
        • Kersschot E
        • et al.
        Contrast-enhanced MR imaging of breast lesions and effect on treatment.
        Eur J Surg Oncol. 2004; 30: 501-507
        • Tamaki Y
        • Akashi-Tanaka S
        • Ishida T
        • et al.
        3D imaging of intraductal spread of breast cancer and its clinical application for navigation surgery.
        Breast Cancer. 2002; 9: 289-295
        • Siegmann KC
        • Müller-Schimpfle M
        • Schick F
        • et al.
        MR imaging-detected breast lesions: histopathologic correlation of lesion characteristics and signal intensity data.
        AJR Am J Roentgenol. 2002; 178: 1403-1409
        • Rieber A
        • Brambs HJ
        • Gabelmann A
        • Heilmann V
        • Kreienberg R
        • Kuhn T
        Breast MRI for monitoring response of primary breast cancer to neo-adjuvant chemotherapy.
        Eur Radiol. 2002; 12: 1711-1719
        • Roth Y
        • Tichler T
        • Kostenich G
        • et al.
        High-b-value diffusion-weighted MR imaging for pretreatment prediction and early monitoring of tumor response to therapy in mice1.
        Radiology. 2004; 232: 685-692
        • Lang P
        • Wendland MF
        • Saeed M
        • et al.
        Osteogenic sarcoma: non-invasive in vivo assessment of tumor necrosis with diffusion weighted MR imaging.
        Radiology. 1998; 206: 227-235
        • Provenzale JM
        • Mukundan S
        • Barboriak DP
        Diffusion-weighted and perfusion MR imaging for brain tumor characterization and assessment of treatment response.
        Radiology. 2006; 239: 632-649
        • Lyng H
        • Haraldseth O
        • Rofstad EK
        Measurement of cell density and necrotic fraction in human melanoma xenografts by diffusion weighted magnetic resonance imaging.
        Magn Reson Med. 2000; 43: 828-836
        • Englander SA
        • Ulug AM
        • Brem R
        • Glickson JD
        • van Zijl PC
        Diffusion imaging of the human breast.
        NMR Biomed. 1997; 10: 348-352
        • Guo Y
        • Cai YQ
        • Cai ZL
        • et al.
        Differentiation of clinically benign and malignant breast lesions using diffusion-weighted imaging.
        J Magn Reson Imaging. 2002; 16: 172-178
        • Sinha S
        • Lucas-Quesada FA
        • Sinha U
        • DeBruhl N
        • Bassett LW
        In vivo diffusion-weighted MRI of the breast: potential for lesion characterization.
        J Magn Reson Imaging. 2002; 15: 693-704
        • Woodhams R
        • Matsunaga K
        • Iwabuchi K
        • et al.
        Diffusion-weighted imaging of malignant breast tumors: the usefulness of apparent diffusion coefficient (ADC) value and ADC map for the detection for malignant breast tumors and evaluation of cancer extension.
        J Comput Assist Tomogr. 2005; 29: 644-649
        • Woodhams R
        • Matsunaqa K
        • Kan S
        • et al.
        ADC mapping of benign and malignant breast tumors.
        Magn Reson Men Sci. 2005; 4: 35-42
        • Gu YJ
        • Feng XY
        • Tang F
        • Peng WJ
        • Mao J
        • Yang WT
        Diffusion-weighted MRI of the breast: potential for lesion characterization and parameter selection.
        Chin J Radiol. 2007; 41: 451-456
        • Kuroki Y
        • Nasu K
        • Kuroki S
        • et al.
        Diffusion-weighted imaging of breast cancer with the sensitivity encoding technique: analysis of the apparent diffusion coefficient value.
        Magn Reson Med Sci. 2004; 3: 79-85
        • Gu YJ
        • Wang XH
        • Xiao Q
        MR imaging evaluation of ductal carcinoma in situ and DCIS with small invasive foci of breast.
        Chin J Radiol. 2007; 41: 248-253
        • Tabar L
        • Fagerberg G
        • Chen HH
        • Duffy SW
        • Gad A
        Tumor development, histology and grade of breast cancers: prognosis and progression.
        Int J Cancer. 1996; 66: 413-419