Abstract
Aim
To investigate the feasibility of using diffusion-weighted MR imaging (DWI) to accurately
measure breast cancer extension.
Materials and Methods
The extensions of 59 breast lesions were investigated on DW images and apparent diffusion
coefficient (ADC) maps and compared to the pathological exams.
Results
Three groups were observed: accurate, overdiagnosis, and false negative. There were
no significant differences seen in accurate or false-negative group when b was 500 and 1000 s/mm2 when two lesions in the overdiagnosis group at both b values.
Conclusion
DWI and the ADC value have potential for evaluating cancer extension.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Clinical ImagingAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Contrast-enhanced MR imaging of breast lesions and effect on treatment.Eur J Surg Oncol. 2004; 30: 501-507
- 3D imaging of intraductal spread of breast cancer and its clinical application for navigation surgery.Breast Cancer. 2002; 9: 289-295
- MR imaging-detected breast lesions: histopathologic correlation of lesion characteristics and signal intensity data.AJR Am J Roentgenol. 2002; 178: 1403-1409
- Breast MRI for monitoring response of primary breast cancer to neo-adjuvant chemotherapy.Eur Radiol. 2002; 12: 1711-1719
- High-b-value diffusion-weighted MR imaging for pretreatment prediction and early monitoring of tumor response to therapy in mice1.Radiology. 2004; 232: 685-692
- Osteogenic sarcoma: non-invasive in vivo assessment of tumor necrosis with diffusion weighted MR imaging.Radiology. 1998; 206: 227-235
- Diffusion-weighted and perfusion MR imaging for brain tumor characterization and assessment of treatment response.Radiology. 2006; 239: 632-649
- Measurement of cell density and necrotic fraction in human melanoma xenografts by diffusion weighted magnetic resonance imaging.Magn Reson Med. 2000; 43: 828-836
- Diffusion imaging of the human breast.NMR Biomed. 1997; 10: 348-352
- Differentiation of clinically benign and malignant breast lesions using diffusion-weighted imaging.J Magn Reson Imaging. 2002; 16: 172-178
- In vivo diffusion-weighted MRI of the breast: potential for lesion characterization.J Magn Reson Imaging. 2002; 15: 693-704
- Diffusion-weighted imaging of malignant breast tumors: the usefulness of apparent diffusion coefficient (ADC) value and ADC map for the detection for malignant breast tumors and evaluation of cancer extension.J Comput Assist Tomogr. 2005; 29: 644-649
- ADC mapping of benign and malignant breast tumors.Magn Reson Men Sci. 2005; 4: 35-42
- Diffusion-weighted MRI of the breast: potential for lesion characterization and parameter selection.Chin J Radiol. 2007; 41: 451-456
- Diffusion-weighted imaging of breast cancer with the sensitivity encoding technique: analysis of the apparent diffusion coefficient value.Magn Reson Med Sci. 2004; 3: 79-85
- MR imaging evaluation of ductal carcinoma in situ and DCIS with small invasive foci of breast.Chin J Radiol. 2007; 41: 248-253
- Tumor development, histology and grade of breast cancers: prognosis and progression.Int J Cancer. 1996; 66: 413-419
Article info
Publication history
Published online: October 26, 2009
Accepted:
May 6,
2009
Received:
April 30,
2009
Identification
Copyright
© 2010 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
