Abstract
A case of Whipple's disease with development of antibiotic resistance is reported.
The patient's symptomatology correlated with evolution of diffusion abnormality rather
than with lesion enhancement. The lesion demonstrated no hyperperfusion, moderately
elevated choline, and decreased N-acetylaspartate.
Conventional magnetic resonance (MR) imaging findings of central nervous system Whipple's
disease are nonspecific and may mimic neoplasm. MR perfusion and spectroscopy findings
are reported, which may assist in diagnosis. Change in diffusion restriction appears
to be a potential imaging indicator of clinical progression and response to therapy.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Clinical ImagingAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Diagnostic guidelines in central nervous system Whipple's disease.Ann Neurol. 1996; 40: 561-568
- Proton magnetic resonance spectroscopy and diffusion-weighted imaging of central nervous system Whipple disease.J Comput Assist Tomogr. 2005; 29: 320-322
- An uncommon cause of recurrent strokes: Tropheryma whippleii endocarditis.Stroke. 2000; 31: 2002-2006
- Cerebral Whipple's disease with a stroke-like presentation and cerebrovascular pathology.J Neurol Neurosurg Psychiatry. 2002; 73: 336-339
- Antibiotic treatment and relapse in Whipple's disease: long term follow-up of 88 patients.Gastroenterology. 1995; 88: 1867-1873
- Novel neuroimaging findings in a patient with cerebral Whipple's disease: a magnetic resonance imaging and positron emission tomography study.J Neuroimaging. 2004; 14: 372-376
- Brain abscess and cystic brain tumor: discrimination with dynamic susceptibility contrast perfusion-weighted MRI.J Comput Assist Tomogr. 2005; 29: 663-667
- Neuro-Whipple confirmed five years after a presumptive diagnosis of primitive CNS vasculitis.J Neurol. 2008; 255: 925-926
- Isolated CNS Whipple disease with a variant of oculofacial-skeletal myorhythmia (OFSM).Neurology. 2007; 69: E12
- Diffuse cortical lesions with hemorrhage in cerebral Whipple's disease.Clin Neurol Neurosurg. 2008; 110: 83-87
- Serial imaging changes of cerebral Whipple's disease.J Neuroimaging. 2007; 17: 81-83
- Primary Whipple's disease of the brain: characterization of the clinical syndrome and molecular diagnosis.QJM. 2006; 99: 609-623
- An unusual case of insomnia associated with Whipple encephalopathy: first case reported from Greece.Neurol Sci. 2005; 26: 174-177
- Whipple disease confined to the central nervous system presenting as a solitary frontal tumor.J Neurosurg. 2004; 101: 336-339
- Whipple's disease with neurological manifestations: case report.Arq Neuropsiquiatr. 2004; 62: 342-346
- Intracerebral Whipple disease: unusual location and bone destruction. Case report.J Neurosurg. 2005; 97: 988-991
- Diffuse lesions in CNS revealed by MR imaging in a case of Whipple disease.AJNR Am J Neuroradiol. 2001; 22: 493-495
- Whipple's disease confined to the central nervous system: case report and review of the literature.Scand J Infect Dis. 1999; 31: 411-414
- Intracerebral Whipple's disease diagnosed by stereotactic biopsy: a case report and review of the literature.Neurosurgery. 1999; 44: 203-209
- Whipple's disease and central nervous system, a case report and a review of the literature.Clin Neurol Neurosurg. 1996; 98: 299-304
- Whipple disease confined to the central nervous system in childhood.AJNR Am J Neuroradiol. 1996; 17: 1589-1591
- Whipple's disease confined to the central nervous system.Neuroradiology. 1996; 38: 325-327
- MR of cerebral Whipple disease.AJNR Am J Neuroradiol. 1995; 16: 1328-1329
- Presumed central nervous system Whipple's disease in a child: case report.Clin Infect Dis. 1995; 20: 883-889
Article info
Publication history
Published online: September 17, 2009
Accepted:
May 5,
2009
Received:
March 10,
2009
Identification
Copyright
© 2010 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
