Imaging of angiogenesis is a challenge for modern imaging. Velocimetry in malignant
breast lesions and density of malignant vessels are very low. In breast imaging, first
results of contrast-enhanced ultrasound were disappointing. Microbubbles are fragile
when examined with high frequency US, commonly used in breast imaging. Second-generation
contrast agents increase intensively the signal level of breast lesions and new sequences
like coherence pulse sequencing might be accurate to detect malignant vessels in breast
lesions for characterization, to assess the extent of infiltrative breast carcinoma
or to evaluate the tumor response after chemotherapy. Another interesting clinical
application is the differentiation between post-operative changes and recurrences.
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© 2009 Published by Elsevier Inc.
