Papillary thyroid carcinoma on sonography



      The purpose of this study is to investigate the characteristics of papillary thyroid carcinomas (PTCs) on color duplex sonography (CDUS).


      We retrospectively reviewed 115 nodules (104 patients) with PTC confirmed by pathology from February 1, 2005, to August 31, 2008. The size, border, calcification, echotexture, hemodynamics (peak systolic velocity and resistance index) of the thyroid nodules and cervical lymph nodes on CDUS were analyzed.


      There was a close relationship between the size of the nodule and the vascularity of the thyroid carcinoma (P=.000). Microcalcification increased the suspicion for malignancy of the thyroid nodule. A hypoechoic thyroid nodule with abundant internal vascularity, ill-defined border and microcalcification was highly suggested PTC.


      CDUS plays an important role in the early detection of PTC and cervical lymph node metastasis, which would provide surgeons with valuable information for planning surgical intervention. Mastering manifestations of PTC on CDUS will improve the accuracy in the diagnosis of PTC. CDUS-guided fine needle aspiration of the thyroid nodule is the standard in the diagnosis of thyroid carcinoma and metastasis pre- and postthyroidectomy.


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        • Zhang LH
        • Sun RC
        • Chen Y
        A clinicopathological analysis of the thyroid carcinoma.
        Chin Clin Oncol. 2003; 2: 121-124
        • Nam Goong IS
        • Kim HY
        • Gong G
        • Lee HK
        • Hong SJ
        • Kim WB
        • Shong YK
        Ultrasonograph guide fine-needle aspiration of thyroid incidentaloma: correlation with pathological findings.
        Clin Endocrinol (oxf). 2004; 60: 21-28
      1. Watters DA, Ahuja AT, Evans RM. Role of ultrasound in the management of thyroid nodules.
        Am J Surg. 1992; 164: 654-657
        • Guan HX
        • Shan ZY
        • Mi XY
        • Wang EH
        • Teng WP
        Incidence of thyroid carcinoma before and after universal salt iodization: an 11-year retrospective analysis of pathological reports.
        J China Med Univ. 2006; 3: 284-285
        • Iribarren C
        • Haselkorn T
        • Tekawa IS
        • Friedman GD
        Cohort study of thyroid cancer in a San Francisco Bay area population.
        Int J Cancer. 2001; 93: 745-750
        • Iannuccilli JD
        • Cronan JJ
        • Monchik JM
        Risk for malignancy of thyroid nodules assessed by sonographic criteria: the need for biopsy.
        J Ultrasound Med. 2004; 23: 1455-1464
        • Papini E
        • Guglielmi R
        • Bianchini A
        • Crescenzi A
        • Taccogna S
        • Nardi F
        • Panunzi C
        • Rinaldi R
        • Toscano V
        • Pacella CM
        Risk of malignancy in nonpalpable thyroid nodules: predictive value of ultrasound and color-Doppler features.
        J Clin Endocrinol Metab. 2002; 87: 1941-1946
        • Taki S
        • Terahata S
        • Yamashita R
        • Kinuya K
        • Nobata K
        • Kakuda K
        • Kodama Y
        • Yamamoto I
        Thyroid calcifications: sonographic patterns and incidence of cancer.
        Clin Imaging. 2004; 28: 368-371
        • Ahuja AT
        • Chow L
        • Chick W
        • King W
        • Metreweli C
        Metastatic cervical nodes in papillary carcinoma of the thyroid: ultrasound and histological correlation.
        Clin Radiol. 1995; 50: 229-231
        • Asa SL
        • Witterick IJ
        • Freeman JL
        Thyroid calcification and its association with thyroid carcinoma.
        Head Neck. 2002; 24: 651-655
        • Jun P
        • Chow LC
        • Jeffrey R
        The sonographic features of papillary thyroid carcinomas.
        Ultrasound Q. 2005; 21: 39-45
        • Tollin SR
        • Mery GM
        • Jelveh N
        • Fallon EF
        • Mikhail M
        • Blumenfeld W
        • Perlmutter S
        The use of fine-needle aspiration biopsy under ultrasound guidance to assess the risk of malignancy in patients with a multinodular goiter.
        Thyroid. 2000; 10: 235-241
        • Chan BK
        • Desser TS
        • McDougall IR
        • Weigel RJ
        • Jeffrey RB
        Common and uncommon sonographic features of papillary thyroid carcinoma.
        J Ultrasound Med. 2003; 22: 1083-1090
        • Wienke JR
        • Chong WK
        • Fielding JR
        • Zou KH
        • Mittelstaedt CA
        Sonographic features of benign thyroid nodules: interobserver reliability and overlap with malignancy.
        J Ultrasound Med. 2003; 22: 1027-1031
        • Kim EK
        • Park CS
        • Chung WY
        New sonographic criteria for recommending fine-needle aspiration biopsy of nonpalpable solid nodules of the thyroid.
        AJR Am J Roentgenol. 2002; 178: 687-691
        • Frates MC
        • Benson CB
        • Doubilet PM
        • Cibas ES
        • Marqusee E
        Can color Doppler sonography aid in the prediction of thyroid nodules?.
        J Ultrasound Med. 2003; 22: 127-131
        • Moon WJ
        • Jung SL
        • Lee JH
        • Na DG
        • Baek JH
        • Lee YH
        • Kim J
        • Kim HS
        • Byun JS
        • Lee DH
        Benign and malignant thyroid nodules: US differentiation — Multicenter Retrospective Study.
        Radiology. 2008; 247: 762-770