Abstract
Objective
To explore the mismatched manifestation between regional cerebral blood flow (rCBF)
and regional cerebral blood volume (rCBV) of astrocytomas.
Methods
Both conventional and perfusion CT were performed on 29 patients with pathologically
confirmed astrocytomas (15 cases in Grades I–II, 14 cases in Grades III–IV). Time-density
curves were plotted, cerebral blood flow and volume maps were generated, and the values
between rCBF and rCBV in the same region of interest (ROI) were compared.
Results
Twelve low-grade astrocytomas showed low or medium values of both rCBF (46.95±22.92
ml ⋅ 100 g−1 ⋅ mm−1) and rCBV (5.74±3.61 ml ⋅ 100 g−1); 12 high-grade astrocytomas showed high values of both rCBF (95.44±42.58 ml ⋅ 100
g−1 ⋅ min−1) and rCBV (9.24±5.32 ml ⋅ 100g−1). These cases exhibited agreement between the values of rCBF and rCBV. However, the
remaining five astrocytomas were mismatched, showing reduced rCBF value and increased
rCBV value in the same ROI. The discrepancy may mislead to an inaccuracy of perfusion
CT in grading gliomas.
Conclusions
The mismatched manifestation between rCBF and rCBV occasionally exists in some areas
of astrocytomas. Hence, attention should be paid to assessments in preoperative grading
of astrocytomas and in monitoring therapeutic effects.
Keywords
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Article info
Publication history
Published online: March 09, 2009
Accepted:
January 14,
2009
Received:
December 20,
2008
Identification
Copyright
© 2009 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
