Abstract
Purpose
To evaluate the performance of a self-contained, battery-driven, vacuum-assisted breast
biopsy (VABB) system for the sampling of clustered breast microcalcifications and
masses under stereotactic guidance.
Methods and materials
A total of 144 patients (median age: 56 years; range: 21–87 years) in four European
breast centers underwent percutaneous 9-gauge (G), stereotactic-guided VABB. The median
lesion size was 11 mm (range 2–60 mm). Patients were biopsied in the prone (n=125) or upright position (n=19). All patients were followed up for at least 24 months.
Results
The stereotactic procedure was successful in 142 (98.6%) of 144 cases, with two cases
cancelled due to either severe patient motion (one case) or failure to detect faint
calcifications (one case). A median of 12 specimens per procedure was obtained. In
39 cases (27.5%), the suspicious lesion could no longer be detected mammographically
after the biopsy procedure. The histological diagnosis was malignancy in 45 (31.7%)
cases. One case of atypical ductal hyperplasia diagnosed preoperatively was upgraded
to ductal carcinoma in situ (DCIS) at operation, giving an overall sensitivity of
97.7% for the vacuum-assisted biopsy procedure. In two cases where DCIS was diagnosed
at vacuum-assisted biopsy, the malignant tissue was apparently completely removed
and could no longer be found at operation. No serious complications occurred. During
the follow-up period, no breast cancers appeared at the location of biopsy. Six patients
dropped out during the follow-up period.
Conclusion
The self-contained, vacuum-assisted biopsy device is well suited for stereotactically
guided breast biopsies, having demonstrated excellent sensitivity and specificity
in the preoperative workup of mammographically detected breast lesions after 2 years
of follow-up.
Keywords
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Article info
Publication history
Published online: February 26, 2009
Accepted:
December 16,
2008
Received:
November 3,
2008
Identification
Copyright
© 2009 Published by Elsevier Inc.
