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Liver perfusion with dynamic multidetector-row computed tomography as an objective method to evaluate the efficacy of chemotherapy in patients with colorectal cancer

Published:November 27, 2008DOI:https://doi.org/10.1016/j.clinimag.2008.10.030

      Abstract

      A total of 24 liver metastases of colorectal cancer were evaluated by dynamic multiphasic CT. Under chemotherapy, follow-up examinations were performed every 3 months. The tumor marker CEA before vs. after chemotherapy correlated with the mean contrast enhancement within the margin of metastases. The total size of metastases correlated with the size of central necrosis as well as with the size of marginal contrast enhancement.
      CT is able to quantify perfusion and local activity of liver metastases to determine the efficacy of chemotherapy.

      Keywords

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      References

        • Parkin DM
        • Pisani P
        • Ferlay J
        Global cancer statistics.
        CA Cancer J Clin. 1999; 49: 33-64
        • Weir HK
        • Thun MJ
        • Hankey BF
        • Ries LA
        • Howe HL
        • Wingo PA
        • Jemal A
        • Ward E
        • Anderson RN
        • Edwards BK
        Annual report to the nation on the status of cancer, 1975-2000, featuring the uses of surveillance data for cancer prevention and control.
        J Natl Cancer Inst. 2003; 95: 1276-1299
        • Leichman L
        The role of chemotherapy in the curative treatment of patients with liver metastases from colorectal cancer.
        Surg Oncol Clin N Am. 2007; 16: 537-556
        • Mandalà M
        • Mosconi S
        • Quadri A
        • Milesi L
        • Labianca R
        Neoadjuvant chemotherapy for patients with liver metastases from colorectal cancer.
        Expert Rev Anticancer Ther. 2007; 7: 887-897
        • Lise M
        • Pilati P
        • Da Pian P
        • Mocellin S
        • Nitti D
        • Corazzino S
        Treatment options for liver metastases from colorectal cancer.
        J Exp Clin Cancer Res. 2003; 22: 149-156
        • Duffy MJ
        • van Dalen A
        • Haglund C
        • Hansson L
        • Holinski-Feder E
        • Klapdor R
        • Lamerz R
        • Peltomaki P
        • Sturgeon C
        • Topolcan O
        Tumour markers in colorectal cancer: European Group on Tumour Markers (EGTM) guidelines for clinical use.
        Eur J Cancer. 2007; 43: 1348-1360
        • Beziat C
        • Pilleul F
        • Yzebe D
        • Lombard-Bohas C
        • Mercier C
        • Valette PJ
        Detection of liver metastases in colorectal cancer on chemotherapy. Comparative study between MRI with teslascan and computed tomography with intravenous contrast media.
        J Radiol. 2004; 85: 307-311
        • Schima W
        • Kulinna C
        • Langenberger H
        • Ba-Ssalamah A
        Liver metastases of colorectal cancer: US, CT or MR?.
        Cancer Imaging. 2005; 23: S149-S156
        • Ong KO
        • Leen E
        Radiological staging of colorectal liver metastases.
        Surg Oncol. 2007; 16: 7-14
        • Albrecht T
        • Hohmann J
        • Oldenburg A
        • Skrok J
        • Wolf KJ
        Detection and characterisation of liver metastases.
        Eur Radiol. 2004; 14: P25-P33
        • Hohmann J
        • Albrecht T
        • Hoffmann CW
        • Wolf KJ
        Ultrasonographic detection of focal liver lesions: increased sensitivity and specificity with microbubble contrast agents.
        Eur J Radiol. 2003; 46: 147-159
        • Hohmann J
        • Albrecht T
        • Oldenburg A
        • Skrok J
        • Wolf KJ
        Liver metastases in cancer: detection with contrast-enhanced ultrasonography.
        Abdom Imaging. 2004; 29: 669-681
        • Arlt G
        • Fuhrmann E
        Ultrasound during follow-up of carcinoma.
        Chirurg. 2007; 78: 449-453
        • Dietrich CF
        • Kratzer W
        • Strobe D
        • Danse E
        • Fessl R
        • Bunk A
        • Vossas U
        • Hauenstein K
        • Koch W
        • Blank W
        • Oudkerk M
        • Hahn D
        • Greis C
        Assessment of metastatic liver disease in patients with primary extrahepatic tumors by contrast-enhanced sonography versus CT and MRI.
        World J Gastroenterol. 2006; 12: 1699-1705
        • Hosch WP
        • Schmidt SM
        • Plaza S
        • Dechow C
        • Schmidt J
        • Ley S
        • Kauffmann GW
        • Hansmann J
        Comparison of CT during arterial portography and MR during arterial portography in the detection of liver metastases.
        AJR Am J Roentgenol. 2006; 186: 1502-1511
        • Sahani DV
        • Holalkere NS
        • Mueller PR
        • Zhu AX
        Advanced hepatocellular carcinoma: CT perfusion of liver and tumor tissue—initial experience.
        Radiology. 2007; 243: 736-743
        • Pandharipande PV
        • Krinsky GA
        • Rusinek H
        • Lee VS
        Perfusion imaging of the liver: current challenges and future goals.
        Radiology. 2005; 234: 661-673
        • Zacharia TT
        • Saini S
        • Halpern EF
        • Sumner JE
        CT of colon cancer metastases to the liver using modified RECIST criteria: determining the ideal number of target lesions to measure.
        AJR Am J Roentgenol. 2006; 186: 1067-1070
        • Miller FH
        • Butier RS
        • Hoff FL
        • Fitzgerald SW
        • Nemcek AA
        • Gore RM
        Using triphasic helical CT to detect focal hepatic lesions in patients with neoplasms.
        AJR Am J Roentgenol. 1998; 171: 643-649
        • Portugaller HR
        • Stacher R
        • Komaz G
        • Aschauer M
        • Hausegger KA
        • Szolar DH
        The value of different spiral CT phases in the detection of liver metastases.
        Fortschr Roentgenstr. 2002; 174: 452-458
        • Morgan B
        • Thomas AL
        • Drevs J
        • Hennig J
        • Buchert M
        • Jivan A
        • Horsfield MA
        • Mross K
        • Ball HA
        • Lee L
        • Mietlowski W
        • Fuxuis S
        • Unger C
        • O'Byrne K
        • Henry A
        • Cherryman GR
        • Laurent D
        • Dugan M
        • Marme D
        • Steward WP
        Dynamic contrast-enhanced magnetic resonance imaging as a biomarker for the pharmacological response of PTK787/ZK 222584, an inhibitor of the vascular endothelial growth factor receptor tyrosine kinases, in patients with advanced colorectal cancer and liver metastases: results from two phase I studies.
        J Clin Oncol. 2003; 21: 3955-3964
        • van Laarhoven HW
        • Klomp DW
        • Rijpkema M
        • Kamm YL
        • Wagener DJ
        • Barentsz JO
        • Punt CJ
        • Heerschap A
        Prediction of chemotherapeutic response of colorectal liver metastases with dynamic gadolinium-DTPA-enhanced MRI and localized 19F MRS pharmacokinetic studies of 5-fluorouracil.
        NMR Biomed. 2007; 20: 128-140
        • Dimitrakopoulou-Strauss A
        • Strauss LG
        • Rudi J
        PET-FDG as predictor of therapy response in patients with colorectal carcinoma.
        Q J Nucl Med. 2003; 47: 8-13
        • Bauer B
        • Veit R
        Dose rates in diagnostic radiology.
        Dtsch Arztebl. 2003; 100: 2087-2088
        • Galanski M
        • Nagel HD
        • Stamm G
        CT radiation exposure risk in Germany.
        Fortschr Roentgenstr. 2001; 173: R1-R66