Spectral appearance and concentrations of the most prominent metabolites are affected
by brain development. This knowledge is essential for the detection of pathological
changes in pediatric patients. This paper discusses specific conditions of MR spectroscopic
examination of children and the effects of age on MR spectra quality and quantitation
of the studied metabolites. Clinical examples show several diseases that are reflected
in changes in 1H MR spectra due to pathological alterations in the biochemical pathways of the observed
metabolites. Attention is given to the main metabolites such as N-acetylpartate, creatine/phosphocreatine, cholines, lactate, inositol, etc.
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© 2009 Published by Elsevier Inc.
