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1H MR Spectroscopy in pediatrics

  • M. Dezortova
    Affiliations
    (MR Unit, Department of Diagnostic and Interventional Radiology, Institute for Clinical and Experimental Medicine, Videnska 1958/9, 140 21 Prague, Czech Republic). Eur J Radiol 2008;67:240-249.
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  • M Hajek
    Affiliations
    (MR Unit, Department of Diagnostic and Interventional Radiology, Institute for Clinical and Experimental Medicine, Videnska 1958/9, 140 21 Prague, Czech Republic). Eur J Radiol 2008;67:240-249.
    Search for articles by this author
      Spectral appearance and concentrations of the most prominent metabolites are affected by brain development. This knowledge is essential for the detection of pathological changes in pediatric patients. This paper discusses specific conditions of MR spectroscopic examination of children and the effects of age on MR spectra quality and quantitation of the studied metabolites. Clinical examples show several diseases that are reflected in changes in 1H MR spectra due to pathological alterations in the biochemical pathways of the observed metabolites. Attention is given to the main metabolites such as N-acetylpartate, creatine/phosphocreatine, cholines, lactate, inositol, etc.
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