Abstract
Purpose
It is very important in the management of patients with differentiated thyroid cancer
(DTC) to precisely localize the foci of I-131 uptake, but it is difficult because
of a lack of anatomic landmarks. The purpose of this study was to investigate the
added value of I-131 single-photon emission computed tomography (SPECT)/computed tomography
(CT) fusion imaging using a hybrid system in patients with DTC.
Methods
Ninety-four patients with DTC underwent I-131 SPECT/CT using a hybrid tomography consisting
of a dual-head variable-angle gamma camera and a low-dose X-ray tube. Results were
compared with I-131 whole-body scan (WBS). SPECT/CT was performed 5–7 days after administration
of a therapeutic dose of I-131. Fusion images were constructed by combining the digital
CT and SPECT images on a computer workstation.
Results
Compared with I-131 WBS, SPECT/CT imaging had improved the precise localization in
21% (20/94) of patients. In addition, SPECT/CT provided additional clinical data in
12 of the patients examined (12/94) and also caused physicians to reconsider the 131I therapeutic approach in 22 patients.
Conclusion
The results of the current study indicate that the addition of I-131 SPECT/CT to WBS
can improve the localization of metastases in patients with DTC. It may also detect
metastases missed by WBS and adjust the therapy plan.
Keywords
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Article info
Publication history
Published online: August 11, 2008
Accepted:
June 2,
2008
Received:
April 20,
2008
Identification
Copyright
© 2009 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
