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Radiologic findings in taxane-induced colitis

  • H. Kaur
    Affiliations
    [NKI: Department of Breast Medical Oncology, Unit 1354, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe, Houston, TX 77030]. Eur J Radiol 2008;66:75-78.
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  • E.M. Loyer
    Affiliations
    [NKI: Department of Breast Medical Oncology, Unit 1354, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe, Houston, TX 77030]. Eur J Radiol 2008;66:75-78.
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  • C.L. David
    Affiliations
    [NKI: Department of Breast Medical Oncology, Unit 1354, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe, Houston, TX 77030]. Eur J Radiol 2008;66:75-78.
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  • H. Sawaf
    Affiliations
    [NKI: Department of Breast Medical Oncology, Unit 1354, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe, Houston, TX 77030]. Eur J Radiol 2008;66:75-78.
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  • R.A. DuBrow
    Affiliations
    [NKI: Department of Breast Medical Oncology, Unit 1354, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe, Houston, TX 77030]. Eur J Radiol 2008;66:75-78.
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  • N.K. Ibrahim
    Affiliations
    [NKI: Department of Breast Medical Oncology, Unit 1354, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe, Houston, TX 77030]. Eur J Radiol 2008;66:75-78.
    Search for articles by this author
      Ischemic colitis in breast cancer patients being treated with taxane-based chemotherapy, which may lead to serious morbidities and even death, has recently been defined as a clinical entity. The purpose of this retrospective study was to evaluate the computed tomography (CT) findings in taxane-related colitis and determine their clinical relevance. CT scans of 41 patients at risk for taxane colitis were reviewed retrospectively for bowel and peritoneal abnormalities. Morphological findings were analyzed and correlated with clinical, pathological, and endoscopic findings. CT scans in 10 of the 41 patients showed a definitely abnormal colon with a thickened wall or distended with fluid, signs that are suggestive of colitis, in the context of the clinical picture. Radiographic changes in patients with taxane colitis are not specific but, in the appropriate context, can suggest the correct diagnosis and guide the patient's management.
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