Ischemic colitis in breast cancer patients being treated with taxane-based chemotherapy,
which may lead to serious morbidities and even death, has recently been defined as
a clinical entity. The purpose of this retrospective study was to evaluate the computed
tomography (CT) findings in taxane-related colitis and determine their clinical relevance.
CT scans of 41 patients at risk for taxane colitis were reviewed retrospectively for
bowel and peritoneal abnormalities. Morphological findings were analyzed and correlated
with clinical, pathological, and endoscopic findings. CT scans in 10 of the 41 patients
showed a definitely abnormal colon with a thickened wall or distended with fluid,
signs that are suggestive of colitis, in the context of the clinical picture. Radiographic
changes in patients with taxane colitis are not specific but, in the appropriate context,
can suggest the correct diagnosis and guide the patient's management.
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© 2008 Published by Elsevier Inc.
