Liver streatosis may evolve into steatohepatitis then cirrhosis with related complications.
It may also contribute to hepatocellular failure, sometimes fatal after major hepatectomy,
especially in the setting of liver transplantation with living donor. Imaging must
allow noninvasive detection and accurate quantification. In- and out-of-phase magnetic
resonance imaging routinely performed in clinical practice is a simple robust means
of achieving these goals. In this article, we will review the histological, pathophysiologic,
and clinical features of liver streatosis and the key points of in and out phase pulse
sequences and underlying physical principles. The T2
relaxation, cause of a loss of signal between both echo times, must be taken into
account. Echo times must be known for image interpretation and optimized especially
at 3 T. Finally the T1 of lipids and water is different and causes T1 effects that may lead to quantification errors while being advantageous for image
interpretation. The combination of these factors allows detection and quantification
of liver streatosis in routine clinical practice.
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© 2008 Published by Elsevier Inc.
