Abstract
Purpose
To describe the frequency and findings of pulmonary lymphoma in asymptomatic people
undergoing computed tomographic (CT) screening for lung cancer.
Methods
All lymphoma diagnoses resulting from CT screening of 31 567 at-risk subjects (median
age, 61 years) were identified, and the CT images were reviewed to document the lesions
as to number, location, density, shape, and margin. The presence of lymphadenopathy
and pleural effusion was also documented.
Results
Five patients with pulmonary lymphoma were identified. The lymphoma was a B-cell lymphoma
in three, Hodgkin's lymphoma in one, and malignant lymphoma in one; it was primary
in four and secondary in one. One patient had two lesions; the other four patients
each had one lesion. Four of the six lesions were a mass, and two were a nodule. Four
of the lesions had irregular margins. Air bronchograms were seen in three. Growth
assessment was useful in leading to decisions for biopsy.
Conclusion
In a context of CT screening to detect lung cancer in asymptomatic volunteers, the
diagnosis of pulmonary lymphoma was rare but, nevertheless, occurred in five (.016%)
of 31 567 volunteers.
Keywords
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References
- Primary Hodgkin's disease of the lung.Pathology. 1995; 27: 111-114
- Primary pulmonary Hodgkin's disease: a clinicopathologic study of 15 patients.Cancer. 1986; 57: 1217-1224
- Primary pulmonary Hodgkin's disease: CT findings in three patients.Clin Radiol. 1999; 54: 182-184
- Imaging of pulmonary lymphomas.AJR Am J Roentgenol. 1997; 168: 339-345
- Primary pulmonary lymphoma: a clinical and immunohistochemical study of six cases.Cancer. 1985; 56: 805-813
- Primary pulmonary lymphomas: a clinicopathologic analysis of 36 cases.Cancer. 1984; 54: 1397-1406
- Primary non-Hodgkin's lymphoma of the lung.Ann Thorac Surg. 2000; 69: 993-997
- Survival of patients with stage I lung cancer detected on CT screening.N Engl J Med. 2006; 355: 1763-1771
- Screening for lung cancer: the Early Lung Cancer Action approach.Lung Cancer. 2002; 35: 143-148
- I-ELCAP protocol.(Website:) (Accessed January 19, 2007)
- CT screening for lung cancer: frequency and significance of part-solid and nonsolid nodules.AJR Am J Roentgenol. 2002; 178: 1053-1057
- Report of the Committee on Hodgkin's Disease Staging Classification.Cancer Res. 1971; 31: 1860-1861
- Primary pulmonary lymphoma.Ann Thorac Surg. 2005; 80: 1248-1253
- Pulmonary MALT lymphoma: imaging findings in 24 cases.Eur Radiol. 2000; 10: 1932-1938
- Computed tomography features of primary pulmonary non-Hodgkin's lymphoma.Clin Radiol. 1999; 54: 438-443
- Endobronchial presentation of Hodgkin lymphoma: a review of the literature.Ann Thorac Surg. 2003; 76: 967-972
- Radiographic distribution of intrathoracic disease in previously untreated patients with Hodgkin's disease and non-Hodgkin's lymphoma.Radiology. 1976; 120: 277-281
- Primary lung small B-cell lymphoma versus lymphoid hyperplasia. Evaluation of diagnostic criteria in 26 cases.Am J Surg Pathol. 2002; 26: 76-81
- Primary pulmonary lymphomas. A clinical study of 70 cases in nonimmunocompromised patients.Chest. 1993; 103: 201-208
- Role of surgery in the treatment of primary pulmonary B-cell lymphoma.Ann Thorac Surg. 2007; 83: 236-240
- Pulmonary mucosa-associated lymphoid tissue lymphoma: CT and pathologic findings.AJR Am J Roentgenol. 1999; 172: 1321-1326
- B-cell lymphoma of bronchus-associated lymphoid tissue (BALT): CT features in 10 patients.J Comput Assist Tomogr. 2000; 24: 30-34
- Bronchial-associated lymphoid tissue lymphoma: a clinical study of a rare disease.Eur J Cancer. 2004; 40: 1320-1326
- Bronchus associated lymphoid tissue (BALT) in human lung: its distribution in smokers and non-smokers.Thorax. 1993; 48: 1130-1134
- Lymphoma of the lung: CT findings in 31 patients.AJR Am J Roentgenol. 1991; 156: 711-714
- Primary Hodgkin's disease.Cancer. 1990; 65: 550-563
- Polypoid endobronchial Hodgkin's disease with pneumomediastinum.Br J Radiol. 1999; 72: 392-394
Article info
Publication history
Published online: May 14, 2008
Accepted:
February 22,
2008
Received:
February 1,
2008
Identification
Copyright
© 2008 Published by Elsevier Inc.
