Advertisement

Detection and characterization of focal hepatic lesions: comparative study of MDCT and gadobenate dimeglumine-enhanced MR imaging

  • Ho Yun Lee
    Affiliations
    Department of Radiology and Institute of Radiation Medicine, Seoul National University College of Medicine, Clinical Research Institute, Seoul National University Hospital, Seoul 110-744, Korea
    Search for articles by this author
  • Jeong Min Lee
    Correspondence
    Corresponding author. Department of Radiology, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul 110-744, Korea. Tel.: +82 2 2072 3154; fax: +82 2 743 6385.
    Affiliations
    Department of Radiology and Institute of Radiation Medicine, Seoul National University College of Medicine, Clinical Research Institute, Seoul National University Hospital, Seoul 110-744, Korea
    Search for articles by this author
  • Se Hyung Kim
    Affiliations
    Department of Radiology and Institute of Radiation Medicine, Seoul National University College of Medicine, Clinical Research Institute, Seoul National University Hospital, Seoul 110-744, Korea
    Search for articles by this author
  • Kyung Sook Shin
    Affiliations
    Department of Radiology, Chungnam National University Hospital, Seoul, Korea
    Search for articles by this author
  • Jae Young Lee
    Affiliations
    Department of Radiology and Institute of Radiation Medicine, Seoul National University College of Medicine, Clinical Research Institute, Seoul National University Hospital, Seoul 110-744, Korea
    Search for articles by this author
  • Joon Koo Han
    Affiliations
    Department of Radiology and Institute of Radiation Medicine, Seoul National University College of Medicine, Clinical Research Institute, Seoul National University Hospital, Seoul 110-744, Korea
    Search for articles by this author
  • Byung Ihn Choi
    Affiliations
    Department of Radiology and Institute of Radiation Medicine, Seoul National University College of Medicine, Clinical Research Institute, Seoul National University Hospital, Seoul 110-744, Korea
    Search for articles by this author

      Abstract

      The aim of this study was to compare the diagnostic performance of multidetector row helical CT (MDCT) and gadobenate dimeglumine-enhanced magnetic resonance (MR) imaging (in the detection and characterization of focal liver lesions. Two blind reviewers analyzed the MDCT and MR images of a total of 44 malignant and 85 benign lesions in 46 patients independently. Receiver operating characteristic curves were established to analyze the results for each reviewer and modality.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Clinical Imaging
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Reimer P
        • Jahnke N
        • Fiebich M
        • Schima W
        • Deckers F
        • Marx C
        • Holzknecht N
        • Saini S
        Hepatic lesion detection and characterization: value of nonenhanced MR imaging, superparamagnetic iron oxides-enhanced MR imaging, and spiral CT-ROC analysis.
        Radiology. 2000; 217: 152-158
        • Quillin SP
        • Atilla S
        • Brown JJ
        • Borrello JA
        • Yu CY
        • Pilgram TK
        Characterization of focal hepatic masses by dynamic contrast-enhanced MR imaging: findings in 311 lesions.
        Magn Reson Imaging. 1997; 15: 275-285
        • Fenlon HM
        • Tello R
        • deCarvalho VL
        • Yucel EK
        Signal characteristics of focal liver lesions on double echo T2-weighted conventional spin echo MRI: observer performance versus quantitative measurements of T2 relaxation times.
        J Comput Assist Tomogr. 2000; 24: 204-211
        • Brown JJ
        • Lee JM
        • Lee JK
        • Van Lorn KJ
        • Malchow SC
        Focal hepatic lesions: differentiation with MR imaging at 0.5 T.
        Radiology. 1991; 179: 675-679
        • Choi D
        • Kim S
        • Lim J
        • Lee W
        • Jang H
        • Lee S
        • Lim H
        Preoperative detection of hepatocellular carcinoma: ferumoxides-enhanced MR imaging versus combined CT during arterial portography and CT hepatic arteriography.
        AJR Am J Roentgenol. 2001; 176: 475-482
        • Miller WJ
        • Baron RL
        • Dodd GD
        • Federle MP
        Malignancies in patients with cirrhosis: CT sensitivity and specificity in 200 consecutive transplant patients.
        Radiology. 1994; 193: 645-650
        • Ward J
        • Guthrie JA
        • Scott DJ
        • Atchley J
        • Wilson D
        • Davies MH
        • Wyatt JI
        • Robinson PJ
        Hepatocellular carcinoma in the cirrhotic liver: double-contrast MR imaging for diagnosis.
        Radiology. 2000; 216: 154-162
        • Hu H
        • He HD
        • Foley WD
        • Fox SH
        Four multidetector-row helical CT: image quality and volume coverage speed.
        Radiology. 2000; 215: 55-62
        • Murakami T
        • Kim T
        • Takamura M
        • Hori M
        • Takahashi S
        • Federle MP
        • Tsuda K
        • Osuga K
        • Kawata S
        • Nakamura H
        • Kudo M
        Hypervascular hepatocellular carcinoma: detection with double arterial phase multi-detector row helical CT.
        Radiology. 2001; 218: 763-767
        • Ichikawa T
        • Kitamura T
        • Nakajima H
        • Sou H
        • Tsukamoto T
        • Ikenaga S
        • Araki T
        Hypervascular hepatocellular carcinoma: can double arterial phase imaging with multidetector CT improve tumor depiction in the cirrhotic liver?.
        AJR Am J Roentgenol. 2002; 179: 751-758
        • Schima W
        • Saini S
        • Echeverri JA
        • Hahn PF
        • Harisinghani M
        • Mueller PR
        Focal liver lesions: characterization with conventional spin-echo versus fast spin-echo T2-weighted MR imaging.
        Radiology. 1997; 202: 389-393
        • Lee VS
        • Lavelle MT
        • Krinsky GA
        • Rofsky NM
        Volumetric MR imaging of the liver and applications.
        Magn Reson Imaging Clin N Am. 2001; 9: 697-716
        • Constable RT
        MR physics of body MR imaging.
        Radiol Clin North Am. 2003; 41: 1-15
        • Weiger M
        • Boesiger P
        • Hilfiker PR
        • Weishaupt D
        • Pruessmann KP
        Sensitivity encoding as a means of enhancing the SNR efficiency in steady-state MRI.
        Magn Reson Med. 2005; 53: 177-185
        • Pandharipandle PV
        • Krinsky GA
        • Rusineck H
        • Lee VS
        Perfusion imaging of the liver: current challenges and future goals.
        Radiology. 2005; 234: 661-673
        • Kirchin MA
        • Pirovano G
        • Spinazzi A
        Gadobenate dimeglumine (Gd-BOPTA): an overview.
        Invest Radiol. 1998; 33: 798-809
        • Cavagna FM
        • Maggioni F
        • Castelli PM
        • Dapra M
        • Imperatori LG
        • Lorusso V
        • Jenkins BG
        Gadolinium chelates with weak binding to serum proteins. A new class of high-efficiency, general purpose contrast agents for magnetic resonance imaging.
        Invest Radiol. 1997; 32: 780-796
        • Petersein J
        • Spinazzi A
        • Giovagnoni A
        • Soyer P
        • Terrier F
        • Lencioni R
        • Bartolozzi C
        • Grazioli L
        • Chiesa A
        • Manfredi R
        • Marano P
        • Van Persijn Van Meerten EL
        • Bloem JL
        • Petre C
        • Marchal G
        • Greco A
        • McNamara MT
        • Heuck A
        • Reiser M
        • Laniado M
        • Claussen C
        • Daldrup HE
        • Rummeny E
        • Kirchin MA
        • Pirovano G
        • Hamm B
        Focal liver lesions: evaluation of the efficacy of gadobenate dimeglumine in MR imaging: a multicenter phase III clinical study.
        Radiology. 2000; 215: 727-736
        • Kim YK
        • Lee JM
        • Kim CS
        Gadobenate dimeglumine-enhanced liver MR imaging: value of dynamic and delayed imaging for the characterization and detection of focal liver lesions.
        Eur Radiol. 2004; 14: 5-13
        • Kim YK
        • Kim CS
        • Chung GH
        • Kim CY
        • Kim IH
        Detection of liver metastases: gadovenate dimeglumine-enhanced three-dimensional dynamic phases and one-hour delayed phase MR imaging versus superparamagnetic iron oxide-enhanced MR imaging.
        Eur Radiol. 2005; 15: 220-228
        • Obuchowski NA
        ROC analysis.
        AJR Am J Roentgenol. 2005; 184: 364-372
        • Couinard C
        Surgical anatomy of the liver: revisited.
        Personal, Paris1989
        • Semelka RC
        • Martin DR
        • Balci NC
        Focal lesions in normal liver.
        J Gastroeneterol Hepatol. 2005; 20: 1478-1487
        • Semelka RC
        • Martin DR
        • Balci C
        • Lance T
        Focal liver lesions: comparison of dual-phase CT and multisequence multiplanar MR imaging including dynamic gadolinium enhancement.
        J Magn Reson Imaging. 2001; 13: 397-401
        • Hori M
        • Murakami T
        • Kim T
        • Tomoda K
        • Nakamura H
        CT scan and MRI in the differentiation of liver tumors.
        Dig Dis. 2004; 22: 39-55
        • Baron RL
        • Oliver JH
        • Dodd GD
        • Nalesnik M
        • Holbert BL
        • Carr B
        Hepatocellular carcinoma: evaluation with biphasic, contrast-enhanced, helical CT.
        Radiology. 1996; 199: 505-511
        • Kim MJ
        • Kim JH
        • Chung JJ
        • Park MS
        • Lim JS
        • Oh YT
        Focal hepatic lesions: detection and characterization with combination gadolinium- and superparamagnetic iron oxide-enhanced MR imaging.
        Radiology. 2003; 228: 719-726
        • Krinsky GA
        • Lee VS
        • Theise ND
        • Weinreb JC
        • Rofsky NM
        • Diflo T
        • Teperman LW
        Hepatocellular carcinoma and dysplastic nodules in patients with cirrhosis: prospective diagnosis with MR imaging and explantation correlation.
        Radiology. 2001; 219: 445-454
        • Earls J
        • Theise N
        • Weinreb JC
        • DeCorato DR
        • Krinsky GA
        • Rofsky NM
        • Mizrachi H
        • Teperman LW
        Dysplastic nodules and hepatocellular carcinoma: thin-section MR imaging of explanted cirrhotic livers with pathologic correlation.
        Radiology. 1996; 201: 207-214
        • Jang HJ
        • Lim JH
        • Lee SJ
        • Park CK
        • Park HS
        • Do YS
        Hepatocellular carcinoma: are combined CT during arterial portography and CT hepatic arteriography in addition to triple-phase helical CT all necessary for preoperative evaluation?.
        Radiology. 2000; 215: 373-380
        • Kang BK
        • Lim JH
        • Kim SH
        • Choi D
        • Lim HK
        • Lee WJ
        • Lee SJ
        Preoperative depiction of hepatocellular carcinoma: ferumoxides-enhanced MR imaging versus triple-phase helical CT.
        Radiology. 2003; 226: 79-85
        • Kim SH
        • Choi D
        • Kim SH
        • Lim JH
        • Lee WJ
        • Kim MJ
        • Lim HK
        • Lee SJ
        Ferucarbotran-enhanced MRI versus triple-phase MDCT for the preoperative detection of hepatocellular carcinoma.
        AJR Am J Roentgenol. 2005; 184: 1069-1076
        • Kundel HL
        • Polansky M
        Measurement of observer agreement.
        Radiology. 2003; 228: 303-308
        • Kim YK
        • Kim CS
        • Chung GH
        • Han YM
        • Lee SY
        • Chon SB
        • Lee JM
        Comparison of gadobenate dimeglumine-enhanced dynamic MRI and 16-MDCT for the detection of hepatocellular carcinoma.
        AJR Am J Roentgenol. 2006; 186: 149-157
        • Holland AE
        • Hecht EM
        • Hahn WY
        • Kim DC
        • Babb JS
        • Lee VS
        • West AB
        • Krinsky GA
        Importance of small (< or = 20-mm) enhancing lesions seen only during the hepatic arterial phase at MR imaging of the cirrhotic liver: evaluation and comparison with whole explanted liver.
        Radiology. 2005; 237: 938-944
        • Coates GG
        • Borrello JA
        • McFarland EG
        • Mirowitz SA
        • Brown JJ
        Hepatic T2-weighted MRI: a prospective comparison of sequences, including breath-hold, half-Fourier turbo spin echo (HASTE).
        J Magn Reson Imaging. 1998; 8: 642-649
        • Imanishi Y
        • Fukui A
        • Niimi H
        • Itoh D
        • Nozaki K
        • Nakaji S
        • Ishizuka K
        • Tabata H
        • Furuya Y
        • Uzura M
        • Takahama H
        • Hashizume S
        • Arima S
        • Nakajima Y
        Radiation-induced temporary hair loss as a radiation damage only occurring in patients who had the combination of MDCT and DSA.
        Eur Radiol. 2005; 15: 41-46