Abstract
Background and Purpose
Our intent was to clarify the usefulness of proton magnetic resonance spectroscopy
(MRS) and perfusion-weighted magnetic resonance imaging (PW-MRI) in the grading of
glioma.
Methods
Twenty-three consecutive patients with gliomas were investigated by both proton MRS
and PW-MRI. For quantitative analysis, the metabolite data of the gliomas were estimated
using the LCModel software. Receiver operating characteristic (ROC) curve analyses
were also performed to assess which metabolite parameter was optimal for discrimination
of glioma grade. From the PW-MRI data, the value of blood volume was measured on the
parametric map corresponding to the location of MRS analysis. We then compared tumor
blood volume with the amount of choline (Cho).
Results
The mean Cho/creatine (Cre) ratio was useful to discriminate between Grades II and
III, and the mean lactate (Lac)/Cre ratio was found to be significantly different
between Grades III and IV. ROC curve analysis showed that measurements involving Cho
were superior indices for grading glioma compared with blood volume information. Furthermore,
the correlation between tumor blood volume and the amount of choline was statistically
significant.
Conclusion
MRS may provide valuable information for glioma grading.
Keywords
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Article info
Publication history
Published online: March 25, 2008
Accepted:
December 1,
2007
Received in revised form:
November 1,
2007
Received:
April 12,
2007
Identification
Copyright
© 2008 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
