Noninvasive assessment of liver disease—measurement of hepatic fibrosis using tissue strain imaging


      The development of hepatic fibrosis in patients with liver disease is associated with an increased risk of liver cancer. Assessing the degree of hepatic fibrosis is therefore one of the most important factors in treatment planning. Liver biopsy is commonly performed to assess hepatic fibrosis, but this method is associated with complications such as hemorrhage. Recently, a number of studies on the noninvasive assessment of hepatic fibrosis have appeared in the literature. The present study was conducted to determine whether an easily performed myocardial examination technique can also be applied to the assessment of hepatic fibrosis. The statistical software Minitab, which performs hypothesis testing based on the P value, was used for statistical analysis. The mean strain values were 0.26 in the normal adult group, 0.155 in the chronic hepatitis group, and 0.058 in the cirrhosis group. Statistically significant differences were observed between the groups. The results of the present study suggest that noninvasive tissue strain imaging may become the method of choice for assessing hepatic fibrosis in routine clinical practice.


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        • Goto K
        • Mikami T
        • Onozuka H
        • et al.
        Role of left ventricular regional diastolic abnormalities for global diastolic dysfunction in patients with hypertrophic cardiomyopathy.
        J Am Soc Echocardiogr. 2006; 19: 857-864
        • Goebel B
        • Arnold R
        • Koletzki E
        • et al.
        Exercise tissue Doppler echocardiography with strain rate imaging in healthy young individuals: feasibility, normal values and reproducibility.
        Int J Cardiovasc Imaging. 2006; 26: 1569-1573
        • Thomas L
        • McKay T
        • Byth K
        • et al.
        Abnormalities of left atrial function after cardioversion: an atrial strain rate study.
        Heart. 2006; 93: 89-95
        • Urheim S
        • Edvardsen T
        • Torp H
        • et al.
        Myocardial strain by Doppler echocardiography: validation of a new method to quantify regional myocardial function.
        Circulation. 2000; 102: 1158-1164
        • Kawagishi T
        TDI application measurements.
        Toshiba Medical Review. 1999; 68: 21-25
        • Abe Y
        New cardiovascular applications of Aplio—features and usefulness of TDI-Q.
        Toshiba Medical Review. 2003; 27: 29-32
        • Kawamoto M
        • Mizuguchi T
        • Katsuramaki T
        • et al.
        Assessment of liver fibrosis by a noninvasive method of transient elastography and biochemical markers.
        World J Gastroenterol. 2006; 12: 4325-4330
        • Kazemi F
        • Kettaneh A
        • Nkontchou G
        • et al.
        Liver stiffness measurement selects patients with cirrhosis at risk of bearing large oesophageal varices.
        J Hepatol. 2006; 45: 230-235
        • Castera L
        • Vergniol J
        • Foucher J
        • et al.
        Prospective comparison of transient elastography, Fibrotest, APRI and liver biopsy for the assessment of fibrosis in chronic hepatitis C.
        Gastroenterology. 2005; 128: 343-350
        • Ziol M
        • Handra-Luca A
        • Kettaneh A
        • et al.
        Noninvasive assessment of liver fibrosis by measurement of stiffness in patients with chronic hepatitis C.
        Hepatology. 2005; 41: 48-54
        • Foucher J
        • Chanteloup E
        • Vergniol J
        • et al.
        Diagnosis of cirrhosis by transient elastography (FibroScan): a prospective study.
        Gut. 2006; 55: 403-408
        • Colletta C
        • Smirne C
        • Fabris C
        • et al.
        Value of two noninvasive methods to detect progression of fibrosis among HCV carriers with normal aminotransferases.
        Hepatology. 2005; 42: 838-845
        • Morishima C
        • Morgan TR
        • Everhart JE
        • et al.
        HCV RNA detection by TMA during the hepatitis C antiviral long-term treatment against cirrhosis (Halt-C) trial.
        Hepatology. 2006; 44: 360-367
        • Fontana RJ
        • Sanyal AJ
        • Mehta S
        • et al.
        Portal hypertensive gastropathy in chronic hepatitis C patients with bridging fibrosis and compensated cirrhosis: results from the HALT-C trial.
        Am J Gastroenterol. 2006; 101: 983-992