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Indeterminate small, low-attenuating hepatocellular nodules on helical CT in patients with chronic liver disease: 2-year follow-up

  • Author Footnotes
    1 Current address: Department of Radiology, Ilsan Park Hospital, Inje University Medical School, Ilsan, Korea.
    Jung Wook Seo
    Footnotes
    1 Current address: Department of Radiology, Ilsan Park Hospital, Inje University Medical School, Ilsan, Korea.
    Affiliations
    Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-dong, Kangnam-ku, Seoul 135-710, Republic of Korea
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  • Jae Hoon Lim
    Correspondence
    Corresponding author. Tel.: +82 2 3410 2501; fax: +82 2 3410 2559.
    Affiliations
    Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-dong, Kangnam-ku, Seoul 135-710, Republic of Korea
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  • Dongil Choi
    Affiliations
    Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-dong, Kangnam-ku, Seoul 135-710, Republic of Korea
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  • Author Footnotes
    2 Current address: Department of Radiology, Toronto General Hospital, Toronto, Canada.
    Hyun-Jung Jang
    Footnotes
    2 Current address: Department of Radiology, Toronto General Hospital, Toronto, Canada.
    Affiliations
    Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-dong, Kangnam-ku, Seoul 135-710, Republic of Korea
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  • Won Jae Lee
    Affiliations
    Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-dong, Kangnam-ku, Seoul 135-710, Republic of Korea
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  • Hyo Keun Lim
    Affiliations
    Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-dong, Kangnam-ku, Seoul 135-710, Republic of Korea
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  • Author Footnotes
    1 Current address: Department of Radiology, Ilsan Park Hospital, Inje University Medical School, Ilsan, Korea.
    2 Current address: Department of Radiology, Toronto General Hospital, Toronto, Canada.

      Abstract

      To evaluate the clinical significance of indeterminate, small, low-attenuating nodular lesions on helical dynamic computed tomography (CT) in chronic liver diseases, CT images were reviewed retrospectively in 281 patients. Indeterminate, low-attenuating nodular lesions less than 20 mm in diameter were followed for 24 to 35 months. Of 127 nodules in 73 patients, 21 nodules turned out to be hepatocellular carcinomas (16%), 25 nodules (20%) became larger, while the remaining 81 nodules (64%) remained unchanged or disappeared. Some low-attenuating nodules larger than 10 mm in diameter may develop into hepatocellular carcinoma.

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