Abstract
The purpose of this study was to determine the efficacy of diffusion-weighted imaging
(DWI) and magnetization transfer imaging (MTI) in the differential diagnosis of brain
infarct, infection, hamartoma, and tumor in 106 children. The apparent diffusion coefficients
(ADCs) and magnetization transfer ratios (MTRs) of the lesions were compared using
nonparametric tests. There was an inverse relationship between ADC and MTR in subacute/chronic
infarct, infection, hamartoma, arachnoid cyst, and tumor relative to normal brain
parenchyma. Both ADC and MTR were reduced in acute infarct. DWI and MTI had a complementary
role in the differential diagnosis of acute infarct from infection with lower MTR,
from hamartoma with higher ADC, and from low-grade gliomas and benign tumors that
had higher ADCs and lower MTRs. ADCs increased and MTRs decreased with the duration
of infarct and lower tumor grade.
Keywords
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Article info
Publication history
Published online: December 02, 2004
Received in revised form:
July 20,
2004
Received:
June 20,
2004
Identification
Copyright
© 2005 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
