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Small hepatocellular carcinoma

Ultrasonographic findings and histopathologic correlation
  • Kyeong Ah Kim
    Correspondence
    Corresponding author. Department of Radiology, Guro Hospital, Korea University School of Medicine, 97 Gurodong-Gil, Guro-Ku, Seoul 152-703, South Korea. Tel.: +82-2-818-6183; fax: +82-2-863-9282
    Affiliations
    Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-Dong, Kangnam-Ku, Seoul 135-710, South Korea

    Department of Radiology and Medical Science Research Center, Guro Hospital, Korea University School of Medicine, 97 Gurodong-Gil, Guro-Ku, Seoul 152-703, South Korea
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  • Won Jae Lee
    Affiliations
    Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-Dong, Kangnam-Ku, Seoul 135-710, South Korea
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  • Hyo Keun Lim
    Affiliations
    Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-Dong, Kangnam-Ku, Seoul 135-710, South Korea
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  • Cheol Min Park
    Affiliations
    Department of Radiology and Medical Science Research Center, Guro Hospital, Korea University School of Medicine, 97 Gurodong-Gil, Guro-Ku, Seoul 152-703, South Korea
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  • Cheol Keun Park
    Affiliations
    Department of Diagnostic Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-Dong, Kangnam-Ku, Seoul 135-710, South Korea
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  • In Ho Cha
    Affiliations
    Department of Radiology and Medical Science Research Center, Guro Hospital, Korea University School of Medicine, 97 Gurodong-Gil, Guro-Ku, Seoul 152-703, South Korea
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  • Hae Young Seol
    Affiliations
    Department of Radiology and Medical Science Research Center, Guro Hospital, Korea University School of Medicine, 97 Gurodong-Gil, Guro-Ku, Seoul 152-703, South Korea
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      Abstract

      It is known that small hepatocellular carcinoma (HCCs) were usually hypoechoic at ultrasonography (US). In this study, we analyzed US findings of 42 small HCCs less than 2 cm in diameter and correlated them with histopathologic findings. US parameters were tumor size, tumor echogenecity, and morphologic features (peripheral halo, lateral shadow, posterior enhancement, and mosaic pattern), while histopathologic parameters were Edmonson grade and microscopic features (coagulation necrosis, interstitial fibrosis, fatty metamorphosis, sinusoidal dilatation, hemorrhage, encapsulation, and internal septation). One-third of HCCs was not hypoechoic. Tumor echogenecity and morphologic features were variable, regardless of tumor differentiation and microscopic features. In our study, it seemed that US detected histopathologic changes in small HCCs more frequently than previously known, but none of these US findings could suggest a specific histopathologic finding in small HCCs less than 2 cm in diameter.

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