Abstract
Gastroesophageal reflux (GER) is frequently found in association with asthma. Successful
control of GER in these patients may improve in their asthma symptoms. The present
retrospective analysis was undertaken to find out the incidence of GER in asthmatic
children not responding to routine antiasthmatic medications and to find out if there
is a clinical correlation between the symptoms of GER and scintigraphic evidence of
GER in these patients. A total of 126 children with a mean age of 2.31 years and range
6 months to 6 years were evaluated. The children were divided into two groups. Group
I (n=100) consisted of children with asthma but no clinical symptoms of GER. Group II
(n=26) consisted of those children with asthma and clinical symptoms of GER. Radionuclide
scintigraphy was performed with 100–200 μCi (3.7–7.4 MBq) of Tc99m-sulphur colloid.
All 33 out of 126 (26%) children had GER on scintigraphy. In Group I, only 23 (23%)
had reflux while in Group II, 10 (38.5%) had reflux. In conclusion, esophageal scintiscanning
can be used to detect GER in asthmatic children refractory to routine antiasthmatic
medication irrespective of the presence or absence of symptoms suggestive of GER.
Keywords
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References
- Gastroesophageal reflux in asthma: a review of pathogenesis, diagnosis, and therapy.Allergy. 1999; 54: 651-661
- Asthma—United States, 1982–1992.Morb Mortal Wkly Rep. 1995; 43: 952-953
- Prevalence of gastroesophageal reflux symptoms in asthma.Chest. 1996; 109: 316-322
- Field does medical antireflux therapy improve asthma in asthmatics with gastroesophageal reflux? A critical review of the literature.CHEST. 1998; 114: 275-283
- Gastroesophageal reflux IN asthmatics: a double-blind, placebo-controlled crossover study with omeprazole.CHEST. 1999; 166: 1257-1264
- Gastroesophageal reflux in infants and children-comparative accuracy of diagnostic methods.J Pediatr. 1980; 96: 798-803
- Gastroesophageal reflux in children: radionuclide gastroesophagography.AJR. 1980; 135: 1001-1004
- Gastroesophageal scintiscanning in a pediatric population: dosimetry.J Nucl Med. 1986; 27: 1212-1214
- Gastro-oesophageal reflux prevalence and relationship with bronchial reactivity in asthma.Eur Respir J. 1977; 10: 2255-2259
- Most asthmatics have gastroesophageal reflux with or without bronchodilator therapy.Gastroenterology. 1990; 99: 613-620
- The effect on theophylline on the lower esophageal sphincter pressure.Ann Allergy. 1980; 45: 238-241
- Quantitative gastroesophageal reflux and pulmonary function in asthmatic children and normal adults receiving placebo, theophylline, and metaproterenol sulfate therapy.J Allergy Clin Immunol. 1984; 73: 253-258
- Therapeutic aspects of aspiration pneumonitis in experimental animals.Anesthesiology. 1961; 22: 440-443
- Simultaneous tracheal and esophageal pH measurements in asthmatic patients with gastroesophageal reflux.Thorax. 1995; 50: 201-204
- Assessment of a technique for scintigraphic monitoring of pulmonary aspiration of gastric contents in asthmatics with gastroesophageal reflux.Ann Allergy. 1979; 42: 306-308
- The role of the vagus nerve in airway narrowing caused by intraesophageal hydrochloric acid provocation and esophageal distention.Ann Allergy. 1981; 47: 431-434
- Gastro-esophageal reflux and asthma: a possible reflex mechanism.Ann Allergy. 1978; 41: 224-226
- Esophageal stimulation by hydrochloric acid causes neurogenic inflammation in the airways of guinea pigs.J Appl Physiol. 1997; 82: 738-745
- Neuro-immune interactions in the lung.Clin Exp Allergy. 1999; 29: 1309-1319
- TTF-1 and HNF-38 in the developing trachoesophageal fistula: further evidence for the respiratory origin of the distal esophagus.J Pediatr Surg. 1999; 34: 1322-1326
- Association of gastroesophageal reflux (GER) with bronchial asthma.Indian Pediatr. 1995; 32: 1083-1806
- Results of the gastroesohageal reflux assessment in wheezy children.Indian J Pediatr. 1999; 66: 351-355
Article info
Publication history
Received:
March 10,
2002
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© 2003 Elsevier Inc. Published by Elsevier Inc. All rights reserved.