Abstract
The purpose of this study was to investigate the efficacy of sonography and the frequency
of indeterminate sonographic examinations in the evaluation of patients with suspected
lower extremity deep vein thrombosis (DVT). We prospectively evaluated 136 symptomatic
patients (157 extremities) with suspected DVT using sonography and contrast-enhanced
venography (n=106 patients, 115 extremities). Using venography as the reference standard for diagnosing
DVT, the sensitivity and specificity of sonography was 92.8% and 98%, respectively,
yielding an accuracy of 96.8%. The frequency of indeterminate examinations for calf
DVT was 32.4%. One (0.7%) fatal pulmonary embolus occurred in our patients. The pulmonary
embolism (PE) rate was 1.6% after lower extremity sonography with negative results.
Sonography is highly accurate in detecting lower extremity DVT in symptomatic patients.
Because of the high frequency of indeterminate studies in the calf and the associated
possible risk of pulmonary emboli, we urge radiologists exercise additional caution
when evaluating symptomatic patients with clinically suspected lower extremity DVT.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Clinical ImagingAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Management of deep vein thrombosis and pulmonary embolism.Circulation. 1996; 93: 2212-2245
- Pulmonary embolism: epidemiology.Chest. 1995; 107: 3S-9S
- Antithrombotic therapy for venous thromboembolic disease.Chest. 1998; 114: 561S-578S
- Venous thrombosis and pulmonary embolism.Surg Gynecol Obstet. 1975; 141: 626-631
- Pulmonary embolism: where the problem is not.JAMA. 1976; 236: 1500
- Natural history of pulmonary embolism.Prog Cardiovasc Dis. 1975; 17: 257-270
- Deep vein thrombosis: detection and prevention.Circulation. 1975; 51: 8-19
- Optimal management of suspected lower-extremity deep vein thrombosis.Arch Intern Med. 1992; 152: 165-175
- Symptomatic lower extremity deep venous thrombosis: accuracy, limitations, and role of color duplex flow imaging in diagnosis.Radiology. 1990; 175: 639-644
- Deep venous thrombosis of the lower extremity: US evaluation.Radiology. 1987; 163: 747-751
- Deep venous thrombosis: US assessment using vein compression.Radiology. 1987; 162: 191-194
- Insensitivity of color Doppler flow imaging for detection of acute calf deep venous thrombosis in asymptomatic postoperative patients.J Vasc Interv Radiol. 1993; 4: 111-117
- Accuracy of sonography in the evaluation of calf deep vein thrombosis in both postoperative surveillance and symptomatic patients.Am J Roentgenol. 1996; 166: 1361-1367
- Utility of leg ultrasonography in suspected symptomatic isolated calf deep venous thrombosis.Am J Med. 1995; 99: 43-47
- Deep venous thrombosis of the leg: US findings.Radiology. 1987; 163: 743-746
- Lower-extremity deep venous thrombosis: further experience with and refinements of US assessment.Radiology. 1988; 168: 101-107
- Clinical features and diagnosis of venous thrombosis.J Am Coll Cardiol. 1986; 8: 114-127
- Problems of acute deep venous thrombosis: I. The interpretation of signs and symptoms.Angiology. 1969; 20: 219-223
- The diagnosis of deep venous thrombosis: fallibility of clinical symptoms and signs.Arch Surg. 1976; 111: 34-36
- Deep venous thrombosis of the lower extremities: correlation of clinical findings and cardinal features on venography.Emerg Radiol (Proc). 2000; 7: 193
- Deep venous thrombosis of the lower extremities: correlation of clinical findings and cardinal features on venography.Am Soc Emerg Radiol (ASER). 2000; 134
- Noninvasive objective tests for the diagnosis of clinically suspected deep vein thrombosis.Haemostasis. 1995; 25: 27-39
- Improvements in the diagnostic approach for patients with suspected deep vein thrombosis or pulmonary embolism.Thromb Haemostasis. 1999; 82: 878-886
- Distribution of acute lower extremity deep venous thrombosis in symptomatic and asymptomatic patients: imaging implications.J Ultrasound Med. 1994; 13: 243-250
- Isolated calf venous thrombosis: diagnosis with compression US.Radiology. 1991; 179: 443-446
- Is embolic risk conditioned by location of deep venous thrombosis?.Ann Intern Med. 1981; 94: 439-444
- Late results in deep vein thrombosis of the lower extremity.Vasa. 1985; 14: 264-268
- Calf sonography for detecting deep venous thrombosis in symptomatic patients: experience and review of the literature.J Clin Ultrasound. 1999; 27: 415-420
- Clinical outcomes of untreated symptomatic patients with negative findings on sonography of the thigh for deep vein thrombosis: our experience and a review of the literature.Am J Roentgenol. 1999; 172: 1601-1604
- Clinically important pulmonary emboli: does calf vein US alter outcomes?.Radiology. 1999; 211: 25-29
- Calf deep venous thrombosis: a wolf in sheep's clothing?.Arch Intern Med. 1988; 148: 2131-2138
- A comparison of real-time compression ultrasonography with impedance plethysmography for the diagnosis of deep vein thrombosis in symptomatic out-patients.N Engl J Med. 1993; 329: 1365-1369
- Outcome analysis of patients with normal compression US ecaminations.Radiology. 1990; 175: 645-649
- Significance of a negative duplex scan in patients suspected of having acute deep venous thrombosis of the lower extremity.J Vasc Technol. 1989; 13: 224-226
Article info
Identification
Copyright
© 2003 Elsevier Science Inc. Published by Elsevier Inc. All rights reserved.