Abstract
The presence or absence of fat in lesions can have important diagnostic implications.
Current MR techniques for the evaluation of fat within lesions in the body rely on
indirect imaging methods. The goal of this study was to develop a rapid clinically
practical proton spectroscopy procedure for the direct observation of a localized
fat–water signal within the body. The technique developed reliably determined fat–water
ratios in phantoms and from lesions in vivo in 6 s with single voxel sizes as small
as 0.125 cc.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Clinical ImagingAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- MR spectroscopy: a powerful tool for investigating brain function and neurological diseases.Neurochem Res. 2000; 25: 1365-1372
- Proton MR spectroscopy of the brain.Neuroimaging Clin N Am. 1999; 9: 379-395
- MR spectroscopy in pediatric neuroradiology.Magn Reson Imaging Clin North Am. 2001; 9: 165-189
- Clinical applications of magnetic resonance spectroscopy.Magn Reson Q. 1994; 10: 191-247
- Observation of intramyocellular lipids by 1H-magnetic resonance spectroscopy.Ann NY Acad Sci. 2000; 904: 25-31
- The biophysical basis of tissue contrast in extracranial MR imaging.Am J Roentgenol. 1987; 149: 831-837
- Influence of membrane lipid packing on T2-weighted magnetic resonance images: study of relaxation parameters in model membrane systems.Magn Reson Med. 1996; 36: 420-426
- Discrimination of metabolite from lipid and macromolecule resonances in cerebral infarction in humans using short echo proton spectroscopy.J Magn Reson Imaging. 1997; 7: 1116-1121
- Influence of membrane lipid packing on T2-weighted magnetic resonance images: study of relaxation parameters in model membrane systems.Magn Reson Med. 1996; 36: 420-426
- Effect of voxel position on single-voxel MR spectroscopy findings.Am J Neuroradiol. 2000; 21: 367-374
- Simple proton spectroscopic imaging.Radiology. 1984; 153: 189-194
- Three-point Dixon technique for true water/fat decomposition with B0 inhomogeneity correction.Magn Reson Med. 1991; 18: 371-383
- Temperature-induced fusion of small unilamellar vesicles formed from saturated long-chain lecithins and diheptanoylphosphatidylcholine.Biochemistry. 1989; 28: 8206-8213
- Hematologic bone marrow disorders: quantitative chemical shift MR imaging.Radiology. 1988; 169: 799-804
- Proton-MR spectroscopy of the spinal bone marrow. An analysis of physiological signal behavior.Radiologe. 2000; 40: 694-699
- In vivo evaluation of the effects of continuous exercise on skeletal muscle triglycerides in trained humans.Lipids. 2000; 35: 1313-1318
- Fatty infiltration of the liver. Quantification by 1H localized magnetic resonance spectroscopy and comparison with computed tomography.Invest Radiol. 1993; 28: 297-302
- Comparison of localized proton NMR signals of skeletal muscle and fat tissue in vivo: two lipid compartments in muscle tissue.Magn Reson Med. 1993; 29: 158-167
Article info
Publication history
Accepted:
May 10,
2002
Received:
April 5,
2002
Identification
Copyright
© 2003 Elsevier Science Inc. Published by Elsevier Inc. All rights reserved.
