Abstract
Preoperative mammograms from 395 breast cancers and 132 benign breast lesions were
enrolled for this study. The false-negative (FN) rate for breast cancers from preoperative
reading was 9.6% with 38 breast cancers missed on mammograms. The statistically significant
differences occurred between true-positive (TP) and FN cancers for younger age (P<.025), smaller lesion size (P<.001), denser breast (P<.05), deep retroglandular location (P<.001). None of the FN cancers exhibited calcifications. The FN rate for mammography
for benign breast lesions from preoperative reading was 18.9% with 25 lesions misdiagnosed.
The statistically significant difference between benign TP and FN lesions occurred
for central and subareolar location (P<.025). Exploration of possible factors and imaging features in FN mammograms can
help reduce the FN rate for mammography.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Clinical ImagingAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Analysis of cancers missed at screening mammography.Radiology. 1992; 184: 613-617
- The false-negative mammogram.RadioGraphics. 1998; 18: 1137-1154
- Characteristics of breast carcinomas missed by screening radiologists.Radiology. 1997; 204: 131-135
- Mammographically occult breast cancer: a pathologic and radiologic study.Cancer. 1983; 52: 1810-1819
- Breast cancer missed by mammography.Am J Roentgenol. 1979; 132: 737-739
- Delayed diagnosis of breast cancer as a result of normal mammograms.Arch Surg. 1983; 118: 23-24
- A review of false negative mammography in a symptomatic population.Clin Radiol. 1991; 44: 13-15
- Factors influencing false negative rates in xeromammography.Radiology. 1979; 133: 297-301
- Analysis of clinically occult and mammographically occult breast tumors.Am J Roentgenol. 1977; 128: 403-408
- Features of mammographically negative breast tumors.Br J Surg. 1981; 68: 882-884
- Saunders, PA1997: 447-448 Diagnosis of Diseases of the Breast. 1st edn.
- Lippincott-Raven, PA1998: 388 Breast Imaging. 2nd edn.
- Lippincott-Raven, PA1998: 245 Breast Imaging. 2nd edn.
- Independent double reading of screening mammograms.J Med Screening. 1995; 2: 99-101
- Improvement in mammography interpretation skills in a community radiology practice after dedicated teaching courses: 2-year medical audit of 38.633 cases.Radiology. 1992; 184: 39-43
- Benefit of independent double reading in a population-based mammography screening program.Radiology. 1994; 191: 241-244
- Patients' opinion of mammography screening services: immediate results versus delayed results due to interpretation by two observers.Am J Roentgenol. 1997; 168: 1085-1089
- Mammography screening: an incremental cost effectiveness analysis of double versus single reading of mammograms.Br Med J. 1996; 312: 809-812
- An assessment of the influence of clinical breast examination reports on the interpretation of mammograms in a breast screening program.Breast Cancer Res Treat. 1998; 48: 65-71
Article info
Publication history
Accepted:
May 30,
2000
Received:
January 30,
2000
Identification
Copyright
© 2000 Elsevier Science Inc. Published by Elsevier Inc. All rights reserved.