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Pediatric chest CT radiation dose reduction: protocol refinement based on noise injection for pulmonary nodule detection accuracy

  • Teresa Chapman
    Correspondence
    Corresponding author. Seattle Children's Hospital Department of Radiology, 4800 Sand Point Way NE, Seattle, WA 98105.
    Affiliations
    Department of Radiology, Seattle Children's Hospital, Seattle, WA, USA

    Department of Radiology, University of Washington School of Medicine, Seattle, WA, USA
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  • Jonathan O. Swanson
    Affiliations
    Department of Radiology, Seattle Children's Hospital, Seattle, WA, USA

    Department of Radiology, University of Washington School of Medicine, Seattle, WA, USA
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  • Grace S. Phillips
    Affiliations
    Department of Radiology, Seattle Children's Hospital, Seattle, WA, USA

    Department of Radiology, University of Washington School of Medicine, Seattle, WA, USA
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  • Marguerite T. Parisi
    Affiliations
    Department of Radiology, Seattle Children's Hospital, Seattle, WA, USA

    Department of Radiology, University of Washington School of Medicine, Seattle, WA, USA
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  • Adam M. Alessio
    Affiliations
    Department of Radiology, Seattle Children's Hospital, Seattle, WA, USA

    Department of Radiology, University of Washington School of Medicine, Seattle, WA, USA
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      Abstract

      To establish appropriate chest computed tomography (CT) acquisition protocols that balance radiation dose and diagnostic capability in pediatric bone marrow transplant patients by assessing the accuracy of pulmonary nodule detection at simulated lower-radiation acquisitions, chest CT images from bone marrow transplant patients were reviewed by four pediatric radiologists at artificially reduced CT dose levels (0%, 30%, and 60%). Average accuracy for nodule detection in 31 randomly selected cases was 0.87 at 0% dose reduction, 0.90 at 30% reduction, and 0.86 at 60% reduction. We observed no clinically relevant difference in acceptability of images or accuracy levels with tested dose reductions to 60%.

      Keywords

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