Intraocular tumors the value of spectral and color Doppler sonography

      This paper is only available as a PDF. To read, Please Download here.


      We evaluated the efficacy of spectral and color Doppler sonography as a screening procedure for intraocular tumors. Thirty patients who had intraocular tumors were included in the study. Abnormal Doppler shifts were demonstrated 19 of 20 patients with choroidal malignant melanomas, especially at the base of the tumors. The average maximum systolic blood flow velocity in the vessels of these tumors was 17 ± 6.8 cm/sec (14 to 28 cm/sec). In one of the choroidal metastasis, blood vessels were seen around the lesion with a 14-cm/sec maximum peak systolic velocity. Intratumoral vascularity could not be demonstrated in the other tumors. Spectral and color Doppler imaging is a relatively new and promising modality in the management of intraocular tumors and may help to provide a more precise preoperative histological diagnosis noninvasively; however, long-term follow-up is needed.


      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Clinical Imaging
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Lieb WE
        Color Doppler ultrasonography of the eye and orbit.
        Curr Opin Ophthalmol. 1993; 4: 68-75
        • Grant E
        • Tessler F
        • Perrella R
        Clinical Doppler imaging.
        AJR. 1989; 152: 707-717
        • Merritt C
        Doppler color-flow imaging.
        J Clin Ultrasound. 1987; 15: 591-597
        • Mitchell DG
        Color Doppler imaging: principles, limitations and artifacts.
        Radiology. 1990; 177: 1-10
        • Coleman DJ
        • Rondeau M
        • Silverman RH
        • et al.
        Computerized ultrasonic biometry and imaging of intraocular tumors for the monitoring of therapy.
        Trans Am Ophthalmol Soc. 1987; 95: 49-81
        • Coleman DJ
        • Silverman RH
        • Rondeau MJ
        • et al.
        Correlations of acoustic tissue typing of malignant melanoma and histopathologic features as predictor of death.
        Am J Ophthalmol. 1990; 110: 380-398
        • Guthoff R
        • Berger RW
        • Helmke K
        • et al.
        Doppler sonographische befunde bei intraokularen tumoren.
        Fortschr Ophthalmol. 1989; 86: 239-241
        • Guthoff R
        The characteristics of choroidal melanoma on A-mode echography.
        in: Ultrasound Ophthalmological Diagnosis: A Practical Guide. Verlag, New York1991: 88-91
        • Lieb WE
        • Shields JA
        • Cohen SM
        • et al.
        Color Doppler imaging in the management of intraocular tumors.
        Ophthalmology. 1990; 97: 1660-1664
        • Ossoining KC
        Standardized echography: basic principles, clinical applications and results.
        Int Ophthalmol Clin. 1979; 19: 144-210
        • Feleppa EJ
        • Lizzi FL
        • Coleman DJ
        Diagnostic spectrum analysis in ophthalmology: a physical perspective.
        Ultrasound Med Biol. 1986; 12: 623-631
        • Guthoff R
        • Berger RW
        • Winkler P
        • et al.
        Doppler ultrasonography of malignant melanomas of the uvea.
        Arch Ophthalmol. 1991; 109: 537-541
        • Edwards WC
        • Layton WE
        • McDonald
        Fluorescein angiography of malignant melanomas of the choroid.
        Am J Ophthalmol. 1969; 68: 797-808
        • Hayreh SS
        Choroidal melanomata: fluorescein angiography and histopathologic study.
        Br J Ophthalmol. 1970; 54: 145-160
      1. Hilborn MD, Munk PL, Lin DTC, et al. Sonography of ocular choroidal melanomas. AJR 161: 1253–1257

        • Byrne SF
        Standardized echography of the eye and orbit.
        Neuroradiology. 1986; 28: 618-640
        • Shimamoto K
        • Sakuma S
        • Ishigaki T
        • et al.
        Intratumoral blood flow: evaluation with color Doppler echography.
        Radiology. 1987; 165: 683-685
        • Taylor KJW
        • Ramos I
        • Carter D
        • et al.
        Correlation of Doppler US tumor signals with neovascular morphologic features.
        Radiology. 1988; 166: 57-62
        • Ramos I
        • Taylor KJW
        • Kier R
        • et al.
        Tumor vascular signals in renal masses: detection with Doppler US.
        Radiology. 1988; 168: 633-637
        • Tanaka S
        • Kitamura T
        • Fujita M
        • et al.
        Color Doppler flow imaging of liver tumors.
        AJR. 1990; 154: 509-514
        • Cosgrove DO
        • Bamber JC
        • Davey JB
        • et al.
        Color Doppler signals from breast tumors.
        Radiology. 1990; 176: 175-180
        • Guthoff R
        • Winkler P
        • Helmke K
        • et al.
        Diagnosis and treatment control of choroidal melanomasthe role of B-scan and Doppler technique.
        Acta Ophthalmol Suppl (Copenh). 1992; 204: 59-61
        • Lieb WE
        • Flaharty PM
        • Ho A
        • et al.
        Color Doppler imaging of the eye and orbit. A synopsis of a 400 case experience.
        Acta Ophthalmol Suppl (Copenh). 1992; 204: 50-54
        • Jain R
        • Sawhney S
        • Berry M
        Real-time sonography of the orbital tumors color Doppler characterization: initial experience.
        Acta Ophthalmol Suppl (Copenh). 1992; 204: 46-49