Unusual computed tomographic manifestations of benign metastasizing leiomyomas as cavitary nodular lesions or interstitial lung disease

      This paper is only available as a PDF. To read, Please Download here.


      The unusual computed tomographic manifestations of benign metastasizing leiomyomas diagnosed in two patients 3 Math Eq and 6 years after hysterectomy for uterine fibroids are described. One showed multiple pulmonary nodules with a round or irregular air-filled cavity representing obstructive emphysema. The other showed interstitial lung disease with tumor cells spreading along alveolar septa, the vascular wall, and the bronchial tree. We consider such metastasizing tumors as low-grade leiomyosarcomas.


      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Clinical Imaging
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Steiner PE
        Metastasizing fibroleiomyoma of the uterus: report of a case and review of the literature.
        Am J Pathol. 1939; 15: 89-110
        • Spiro RH
        • McPeak CJ
        On the so-called metastasizing leiomyoma.
        Cancer. 1966; 19: 544-548
        • Horstmann JP
        • Pietra GG
        • Harman JA
        • Cole NG
        • Grinspan S
        Spontaneous regression of pulmonary leiomyomas during pregnancy.
        Cancer. 1977; 39: 314-321
        • Tench WD
        • Dail D
        • Gmelich JT
        • Matani N
        Benign metastasizing leiomyomas: a review of 21 cases.
        Lab Invest. 1978; 38: 37
        • Wolff M
        • Kaye G
        • Silva F
        Pulmonary metastases (with admixed epithelial elements) from smooth muscle neoplasms. Report of nine cases, including three males.
        Am J Surg Pathol. 1979; 3: 325-342
        • Taylor HB
        • Norris HJ
        Mesenchymal tumors of the uterus. IV. Diagnosis and prognosis of leiomyosarcomas.
        Arch Pathol. 1966; 82: 40-44
        • Saksela E
        • Lampiner V
        • Procope BJ
        Malignant mesenchymal tumors of the uterine corpus.
        Am J Obstet Gynecol. 1974; 120: 452-456
        • Logan WD
        • Rhode FC
        • Abbott OA
        • Metzer HD
        Multiple pulmonary fibroleiomyomatous hamartoma.
        Am Rev Respir Dis. 1965; 91: 101-103
        • Sargent EN
        • Barnes RA
        • Schwinn CP
        Multiple pulmonary fibroleiomyomatous hamartomas; report of a case and review of the literature.
        AJR. 1970; 110: 694-700
        • Corrin B
        • Liebow AA
        • Friedman PJ
        Pulmonary lymphangiomyomatosis. A review.
        Am J Pathol. 1975; 79: 348-367
        • Bachman D
        • Wolff M
        Pulmonary metastases from benign-appearing smooth muscle tumors of the uterus.
        AJR. 1976; 127: 441-446
        • Canzonieri V
        • Blandamura S
        • Zanella A
        • Capitanio G
        Uterine benign-appearing smooth muscle tumor “metastatic” to the lung: a case report.
        Tumori. 1990; 76: 513-516
        • Banner AS
        • Carrington CB
        • Emory WB
        • Kittle F
        • Leonard G
        • Ringus J
        • Taylor P
        • Addington WW
        Efficacy of oophorectomy in lymphangioleiomyomatosis and benign metastasizing leiomyoma.
        N Engl J Med. 1981; 305: 204-209
        • Aaro LA
        • Symmonds RE
        • Dockerty MB
        Sarcoma of the uterus.
        Am J Obstet Gynecol. 1966; 94: 101-109
        • Gal AA
        • Brooks JS
        • Pietra GG
        Leiomyomatous neoplasms of the lung: a clinical, histologic, and immunohistochemical study.
        Modern Pathol. 1989; 2: 209-216
        • Cramer SF
        • Meyer JS
        • Kramer JF
        • Camel M
        • Mazur MT
        • Tenenbaum MS
        Metastasizing leiomyoma of the uterus: S-phase fraction, estrogen receptor, and ultrastructure.
        Cancer. 1980; 45: 932-937