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SPECT imaging of Moyamoya disease using 99mTc-HM-PAO comparison with computed tomography findings

  • James M. Mountz
    Correspondence
    Address reprint requests to: James M. Mountz, MD, PhD, Assistant Professor of Internal Medicine, University of Michigan Medical Center, Department of Internal Medicine, Division of Nuclear Medicine, Ann Arbor, Michigan 48109-0028.
    Footnotes
    Affiliations
    Department of Internal Medicine, the Division of Nuclear Medicine, USA

    Department of Neurology, University of Michigan Medical Center, Ann Arbor, Michigan, USA
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  • Norman L. Foster
    Affiliations
    Department of Internal Medicine, the Division of Nuclear Medicine, USA

    Department of Neurology, University of Michigan Medical Center, Ann Arbor, Michigan, USA
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  • Robert J. Ackermann
    Affiliations
    Department of Internal Medicine, the Division of Nuclear Medicine, USA

    Department of Neurology, University of Michigan Medical Center, Ann Arbor, Michigan, USA
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  • Laurie Bluemlein
    Affiliations
    Department of Internal Medicine, the Division of Nuclear Medicine, USA

    Department of Neurology, University of Michigan Medical Center, Ann Arbor, Michigan, USA
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  • Neil A. Petry
    Affiliations
    Department of Internal Medicine, the Division of Nuclear Medicine, USA

    Department of Neurology, University of Michigan Medical Center, Ann Arbor, Michigan, USA
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  • David E. Kuhl
    Affiliations
    Department of Internal Medicine, the Division of Nuclear Medicine, USA

    Department of Neurology, University of Michigan Medical Center, Ann Arbor, Michigan, USA
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  • Author Footnotes
    1 The secretarial assistance of Ms. Michele Curro and Mrs. Annise Johnson is greatly appreciated. We express gratitude to Ms. Meribeth Adams for her assistance in this work and extend our appreciation to the Amersham Corporation for providing the radiopharmaceutical.
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      Abstract

      99mTc-HM-PAO was used to evaluate regional cerebral blood flow in a 26-year-old woman with Moyamoya disease. This patient had an 18-month history of recurrent neurologic deficits and had angiographic evidence of Moyamoya disease. She had used oral contraceptives and cigarettes, but had no other risk factors for stroke. Single photon emission computed tomographic images showed bilateral and asymmetric reductions in blood flow to anterior and lateral brain regions. These findings correlated better with clinical symptomatology and suggested more extensive brain involvement than did computed tomography.

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