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Abstract
A single case of Wilson's hepatolenticular degeneration was imaged by computed tomography
and magnetic resonance (1.5 Tesla). Findings included generalized cerebral atrophy
seen both on computed tomography and magnetic resonance images. T1-weighted images
revealed a slight symmetric hypointensity in the lentiform nuclei and thalamus. T2-weighted
images demonstrated marked symmetric hypointensity in the lentiform nuclei. These
hypointensities are ascribed to the deposition of intracellular hemosiderin (and perhaps
copper), which produce heterogeneous magnetic susceptibility and preferential T2-proton
relaxation. Areas of increased signal activity on T2-weighted images were also seen
in areas of presumed demyelination known to occur in Wilson's disease.
Keywords
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© 1987 Published by Elsevier Inc.