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A single case of Wilson's hepatolenticular degeneration was imaged by computed tomography and magnetic resonance (1.5 Tesla). Findings included generalized cerebral atrophy seen both on computed tomography and magnetic resonance images. T1-weighted images revealed a slight symmetric hypointensity in the lentiform nuclei and thalamus. T2-weighted images demonstrated marked symmetric hypointensity in the lentiform nuclei. These hypointensities are ascribed to the deposition of intracellular hemosiderin (and perhaps copper), which produce heterogeneous magnetic susceptibility and preferential T2-proton relaxation. Areas of increased signal activity on T2-weighted images were also seen in areas of presumed demyelination known to occur in Wilson's disease.
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- Intracranial hematomas: imaging by high-field MR.Radiology. 1985; 157: 87-93
- High-field imaging of superficial siderosis of the central nervous system.J Comput Assist Tomogr. 1985; 9: 972-975
- High field imaging of cerebral venous thrombosis.J Comput Assist Tomogr. 1986; 10: 10-15
- Hereditary disorders of copper metabolism.in: Stanbury J.B. Wyngaarden J.B. Fredrickson D.S. The metabolic basis of inherited disease. McGraw-Hill, New York1978: 1103-1116
- Computed tomography of Wilson's disease.AJNR. 1983; 4: 429-430
- Computed tomography in Wilson's disease.Neurology. 1981; 31: 107-110
- Wilson's disease: clinical correlation with cranial computed tomography.Neuroradiology. 1981; 22: 1-5
- Computed tomography in Wilson's disease. Report of two cases.Ann Neurol. 1979; 50: 102-103
- Computed cranial tomography in Wilson's disease.Neurology. 1979; 29: 866-868
- Wilson's disease of the brain: MR imaging.Radiology. 1985; 157: 137-141
- Nuclear magnetic resonance imaging in Wilson's disease.J Comput Assist Tomogr. 1983; 7: 1-8
- Neuropathology.in: Rosenberg R.N. The clinical neurosciences. Churchhill Livingstone, New York1983: 478
- High-resolution magnetic resonance for mapping brain iron deposition.in: Presented at the 23rd Annual Meeting of the American Society of Neuroradiology, New OrleansFebruary 18–23, 1985
- Histochemical localization of copper with rubeanic acid.Lab Invest. 1956; 5: 299-305
- Adams J.H. Corsellis J.A.N. Duchen L.W. Greenfield's neuropathology. Wiley, New York1984
© 1987 Published by Elsevier Inc.