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Implications of rapid uniform density changes on hepatic computed tomography

  • Donald J. Wenzel
    Correspondence
    Address reprint requests to: Donald J. Wenzel, MD, Department of Radiology/Nuclear Medicine, Uniformed Services University of the Health Sciences, School of Medicine, Bethesda, Maryland 20814.
    Affiliations
    Imaging Branch, Department of Radiology, National Naval Medical Center, Bethesda, Maryland, USA

    Department of Radiology/Nuclear Medicine, Uniformed Services University of the Health Sciences, School of Medicine, Bethesda, Maryland, USA

    National Cancer Institute-Navy Medical Oncology Branch, National Naval Medical Center, Bethesda, Maryland, USA
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  • Gerald Batist
    Affiliations
    Imaging Branch, Department of Radiology, National Naval Medical Center, Bethesda, Maryland, USA

    Department of Radiology/Nuclear Medicine, Uniformed Services University of the Health Sciences, School of Medicine, Bethesda, Maryland, USA

    National Cancer Institute-Navy Medical Oncology Branch, National Naval Medical Center, Bethesda, Maryland, USA
    Search for articles by this author
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      Abstract

      Uniform hepatic density alterations may be due to fatty infiltration or hemochromatosis. Whole liver density pattern changes may occur with rapidity where there is liver fat accumulation or mobilization. Averaged hepatic densities from concomitantly increased fat and iron accumulation can result in a false impression of liver normalcy. Two cases are presented to illustrate these points and the importance of understanding the patterns in terms of pathophysiology and response to treatment.

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