Clinical Imaging
Volume 35, Issue 4 , Pages 266-273, July 2011

Role of carcinoembryonic antigen, magnetic resonance imaging, and positron emission tomography-computed tomography in the evaluation of patients with suspected local recurrence of colorectal cancer

  • Federica Fiocchi

      Affiliations

    • Dipartimento Integrato dei Servizi Diagnostici e per Immagine, Via del Pozzo 71, 41100 Modena, Italy
    • Corresponding Author InformationCorresponding author. Dipartimento Integrato dei Servizi Diagnostici e per Immagine, Azienda Ospedaliero-Universitaria Policlinico di Modena, Via del Pozzo, 71, 41100 Modena, Italy. Tel.: +39 059 4224381; fax: +39 059 4224290.
    • ,
  • Valentina Iotti

      Affiliations

    • Dipartimento Integrato dei Servizi Diagnostici e per Immagine, Via del Pozzo 71, 41100 Modena, Italy
    • ,
  • Guido Ligabue

      Affiliations

    • Dipartimento Integrato dei Servizi Diagnostici e per Immagine, Via del Pozzo 71, 41100 Modena, Italy
    • ,
  • Norma Malavasi

      Affiliations

    • Dipartimento di Oncoematologia, Università di Modena e Reggio Emilia, Via del Pozzo 71, 41100 Modena, Italy
    • ,
  • Gabriele Luppi

      Affiliations

    • Dipartimento di Oncoematologia, Università di Modena e Reggio Emilia, Via del Pozzo 71, 41100 Modena, Italy
    • ,
  • Bruno Bagni

      Affiliations

    • Dipartimento Integrato dei Servizi Diagnostici e per Immagine, Via del Pozzo 71, 41100 Modena, Italy
    • ,
  • Pietro Torricelli

      Affiliations

    • Dipartimento Integrato dei Servizi Diagnostici e per Immagine, Via del Pozzo 71, 41100 Modena, Italy

Received 1 May 2010; accepted 15 July 2010. published online 03 September 2010.

Abstract 

The role of carcinoembryonic antigen (CEA), magnetic resonance imaging (MRI), and positron emission tomography (PET)-computed tomography (CT) in detection of local recurrence of colorectal cancer is evaluated in 71 patients, selected due to suspected relapse at CT follow-up. Recurrence was confirmed by histology in 18 cases and excluded in 25 cases. Sensitivity, specificity, positive and negative predictive values, and accuracy were as follows: 44.4%, 92.5%, 66.7%, 83.1%, and 80.3% for CEA; 88.9%, 73.6%, 53.3%, 95.1%, and 77.5% for MRI; and 94.4%, 73.6%, 54.8%, 97.5%, and 78.9% for PET-CT. A diagnostic protocol integrating CEA and dedicated imaging studies is to be advocated.

Keywords: Colorectal cancer, Local recurrence, CEA, MRI, PET-CT

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PII: S0899-7071(10)00156-7

doi:10.1016/j.clinimag.2010.07.010

Clinical Imaging
Volume 35, Issue 4 , Pages 266-273, July 2011

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