Clinical Imaging
Volume 35, Issue 4 , Pages 253-258, July 2011

Multimodal imaging of recovery of functional networks associated with reversal of paradoxical herniation after cranioplasty☆

  • Henning U. Voss

      Affiliations

    • Department of Radiology and Citigroup Biomedical Imaging Center, Weill Cornell Medical College, New York, NY 10021, USA
    • Corresponding Author InformationCorresponding author. Department of Radiology and Citigroup Biomedical Imaging Center, Weill Cornell Medical College, 516 E 72nd St., New York, NY 10021, USA. Tel.: +1 212 746 5216 (office, msg. box), +1 212 746 5702 (lab); fax: +1 212 746 6681.
    • ,
  • Linda A. Heier

      Affiliations

    • Department of Radiology, Weill Cornell Medical College, New York, NY 10065, USA
    • ,
  • Nicholas D. Schiff

      Affiliations

    • Department of Neurology and Neuroscience, Weill Cornell Medical College, New York, NY 10065, USA

Received 15 June 2010; accepted 16 July 2010. published online 01 September 2010.

Abstract 

Cranioplasty following decompressive craniectomy is reported to result in improved blood flow, cerebral metabolism, and concomitant neurological recovery. We used multimodal functional imaging technology to study a patient with marked neurological recovery after cranioplasty. Resting-state networks and auditory responses obtained with functional MRI and cerebral metabolism obtained with PET before and after cranioplasty revealed significant functional changes that were correlated with the subject's neurological recovery. Our results suggest a link between recovery of behavior, cerebral metabolism, and resting-state networks following cranioplasty.

Keywords: Cranioplasty, Resting-state functional MRI, Functional MRI, Positron emission tomography

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☆ Design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript were supported by the National Institutes of Health National Institute of Child Health and Human Development, the James S. McDonnell Foundation (N.D.S.), the Institute for Biomedical Imaging Sciences, and a Fleming Award from Weill Cornell Medical College (H.U.V).

PII: S0899-7071(10)00154-3

doi:10.1016/j.clinimag.2010.07.008

Clinical Imaging
Volume 35, Issue 4 , Pages 253-258, July 2011

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