The role of dynamic, contrast-enhanced MRI in differentiating lung tumor subtypes

Pauls, Sandra; Breining, Thomas; Muche, Rainer; Schmidt, Stefan A.; Wunderlich, Arthur; Krüger, S.; Brambs, Hans-Jürgen; Feuerlein, Sebastian

doi:10.1016/j.clinimag.2010.07.002

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Volume 35, Issue 4 , Pages 259-265, July 2011

The role of dynamic, contrast-enhanced MRI in differentiating lung tumor subtypes

Sandra Pauls
- Department of Radiology and Nuclear Medicine, Sana Hospitals Lübeck, Kronsforder Allee 71-73, 23560 Lübeck, Germany
- Corresponding author. Tel.: +49 451 585 1450; fax: +49 451 585 1971 1450.
Thomas Breining
- Department of Diagnostic and Interventional Radiology, University Hospital Ulm, Albert-Einstein-Allee 23, 89081 Ulm, Germany
Rainer Muche
- Institute for Biometry, University of Ulm, Schwabstr. 13, 89075 Ulm, Germany
Stefan A. Schmidt
- Department of Diagnostic and Interventional Radiology, University Hospital Ulm, Albert-Einstein-Allee 23, 89081 Ulm, Germany
Arthur Wunderlich
- Department of Diagnostic and Interventional Radiology, University Hospital Ulm, Albert-Einstein-Allee 23, 89081 Ulm, Germany
S. Krüger
- Medical Clinic I, Medical Faculty, RWTH University Aachen, Germany
Hans-Jürgen Brambs
- Department of Diagnostic and Interventional Radiology, University Hospital Ulm, Albert-Einstein-Allee 23, 89081 Ulm, Germany
Sebastian Feuerlein
- Department of Diagnostic and Interventional Radiology, University Hospital Ulm, Albert-Einstein-Allee 23, 89081 Ulm, Germany

Received 1 April 2010; accepted 21 May 2010. published online 27 August 2010.

Abstract

The aim was to correlate dynamic magnetic resonance imaging perfusion parameters of pulmonary tumors with histological tumor classification. Eighty-six patients with lung cancer were examined. A differentiation of non-small cell lung cancer vs. small cell lung cancer was possible with the parameters tumor necrosis, maximum contrast upslope, and the time until the maximum contrast upslope was reached. The beginning of a relevant contrast uptake, the mean time to peak and the time until the maximum contrast upslope was reached allowed a differentiation between squamous cell carcinoma and adenocarcinoma.

Keywords: Dynamic MRI, Perfusion, Lung tumor, Cancer