Renal hemodynamic changes with aging: a preliminary study using CT perfusion in the healthy elderly

Zhao, Hong; Gong, Jingshan; Wang, Yan; Zhang, Zuoquan; Qin, Peixin

doi:10.1016/j.clinimag.2009.06.031

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Volume 34, Issue 4 , Pages 247-250, July 2010

Renal hemodynamic changes with aging: a preliminary study using CT perfusion in the healthy elderly

Hong Zhao
- Department of Radiology, The Fifth Affiliated Hospital of Zhongshan University, Zhuhai 519000, P.R. China
Jingshan Gong
- Department of Radiology, Shenzhen People's Hospital, Second Clinical College, Jinan University, Shenzhen 518020, P.R. China
- Corresponding author. Department of Radiology, Shenzhen People's Hospital, Second Clinical College, Jinan University, Shenzhen 518020, P.R. China. Tel.: +86 755 25533018x2598 (office), 13631635669 (mobile); fax: +86 755 82606036.
Yan Wang
- Department of Radiology, The Fifth Affiliated Hospital of Zhongshan University, Zhuhai 519000, P.R. China
Zuoquan Zhang
- Department of Radiology, The Fifth Affiliated Hospital of Zhongshan University, Zhuhai 519000, P.R. China
Peixin Qin
- Department of Radiology, The Fifth Affiliated Hospital of Zhongshan University, Zhuhai 519000, P.R. China

Received 28 May 2009; accepted 5 June 2009. published online 09 November 2009.

Abstract

Objective

To investigate renal blood flow perfusion parameter changes associated with aging using multislice spiral computed tomography (CT).

Methods

This prospective study was approved by the institute's ethics committee for clinical study and written informed consent was obtained from all subjects. Forty-two consecutive patients who underwent abdominal CT without obvious renal abnormality at plain scanning were enrolled in this study. The renal perfusion scan was carried out using 16-slice spiral CT. The Pearson correlation coefficient was used to examine the correlation between perfusion parameter changes with aging.

Results

In both the cortex and medulla, blood flow (BF) and blood volume (BV) were negatively correlated with age, while time-to-peak (TTP) value and mean transit time (MTT) showed a positive correlation with age. Changes in BF, TTP, and MTT were found to have a statistically significant correlation with age in both the cortex and medulla, while the correlation between BV and age showed no statistical significance.

Conclusion

It is feasible to assess renal hemodynamics changes with aging in the elderly using the current clinically available CT perfusion imaging technology in vivo. It may be helpful in the management of aged patients to familiarize with the renal hemodynamics changes in clinical work-up.

Keywords: Perfusion imaging, Renal, X-ray computed tomography