Diffusion-weighted MRI evaluation of breast cancer extension

Received 30 April 2009; accepted 6 May 2009. published online 26 October 2009.
Corrected Proof

Abstract

Aim

To investigate the feasibility of using diffusion-weighted MR imaging (DWI) to accurately measure breast cancer extension.

Materials and Methods

The extensions of 59 breast lesions were investigated on DW images and apparent diffusion coefficient (ADC) maps and compared to the pathological exams.

Results

Three groups were observed: accurate, overdiagnosis, and false negative. There were no significant differences seen in accurate or false-negative group when b was 500 and 1000 s/mm2 when two lesions in the overdiagnosis group at both b values.

Conclusion

DWI and the ADC value have potential for evaluating cancer extension.

Keywords: Breast cancer, Extension, Magnetic resonance, Diffusion-weighted imaging, Apparent diffusion coefficient

a Department of Radiology, The Affiliated Cancer Hospital of Fudan University, Shanghai 200032, China

b Department of Pathology, The Affiliated Cancer Hospital of Fudan University, Shanghai 200032, China

c Department of Breast Surgery, The Affiliated Cancer Hospital of Fudan University, Shanghai 200032, China

Corresponding author. Department of Radiology, the Affiliated Cancer Hospital of Fudan University, 270 DongAn Road, Shanghai 200032, China. Tel.: +86 21 64175590 6034; fax: +86 21 64433384.

PII: S0899-7071(09)00233-2

doi:10.1016/j.clinimag.2009.09.002