Clinical Imaging
Volume 34, Issue 3 , Pages 172-178 , May 2010

Assessment of COPD severity by computed tomography: correlation with lung functional testing

  • Sandra Pauls

      Affiliations

    • Department of Diagnostic and Interventional Radiology, University Hospitals Ulm, Ulm, Germany
    • Corresponding Author InformationCorresponding author. Department of Diagnostic and Interventional Radiology, University Hospitals of Ulm, Robert-Koch-Str. 8, D-89081 Ulm, Germany. Tel.: +49 731 500 61103; fax: +49 731 500 61105.
    • ,
  • Daniel Gulkin

      Affiliations

    • Department of Diagnostic and Interventional Radiology, University Hospitals Ulm, Ulm, Germany
    • ,
  • Sebastian Feuerlein

      Affiliations

    • Department of Diagnostic and Interventional Radiology, University Hospitals Ulm, Ulm, Germany
    • ,
  • Rainer Muche

      Affiliations

    • Institute of Biometrics, University of Ulm, Ulm, Germany
    • ,
  • Stefan Krüger

      Affiliations

    • Medical Clinic I, University Hospital RWTH Aachen, Germany
    • ,
  • Stefan Andreas Schmidt

      Affiliations

    • Department of Diagnostic and Interventional Radiology, University Hospitals Ulm, Ulm, Germany
    • ,
  • Ekta Dharaiya

      Affiliations

    • CT-Clinical Science, Philips Medical Systems, Cleveland, OH, USA
    • ,
  • Hans-Jürgen Brambs

      Affiliations

    • Department of Diagnostic and Interventional Radiology, University Hospitals Ulm, Ulm, Germany
    • ,
  • Martin Hetzel

      Affiliations

    • Department of Pneumology, Red Cross Hospital Stuttgart, Stuttgart, Germany

Received 10 February 2009 ,Revised 1 May 2009 ,Accepted 30 May 2009.

References 

  1. Slusarcick AL, McCaig LF. National hospital ambulatory medical care survey: 1998 outpatient department summary. Adv Data. 2000;317:1–23
  2. Gold . Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. Executive summery, updated http://www.goldcopd.org2006;
  3. Hersh CP, Washko GR, Jacobson FL, Gill R, Estepar RS, Reilly JJ, et al. Interobserver variability in the determination of upper lobe-predominant emphysema. Chest. 2007;131:424–431
  4. Sashidhar K, Gulati M, Gupta D, Monga S, Suri S. Emphysema in heavy smokers with normal chest radiography. Detection and quantification by HRCT. Acta Radiol. 2002;43:60–65
  5. Achenbach T, Weinheimer O, Buschsieweke C, Heussel CP, Thelen M, Kauczor HU. Fully automatic detection and quantification of emphysema on thin section MD-CT of the chest by a new and dedicated software. Fortschr Roentgenstr. 2004;176:1409–1415
  6. Goldin JG. Quantitative CT of emphysema and the airways. J Thorac Imaging. 2004;19:235–240
  7. Arakawa H, Gevenois PA, Saito Y, Shida H, De Maertelaer V, Morikubo H, et al. Silicosis: expiratory thin-section CT assessment of airway obstruction. Radiology. 2005;236:1059–1066
  8. Aziz ZA, Wells AU, Desai SR, Ellis SM, Walker AE, MacDonald S, et al. Functional impairment in emphysema: contribution of airway abnormalities and distribution of parenchymal disease. Am J Roentgenol. 2005;185:1509–1515
  9. Cerveri I, Dore R, Corsico A, Zoia MC, Pellegrino R, Brusasco V, et al. Assessment of emphysema in COPD: a functional and radiologic study. Chest. 2004;125:1714–1718
  10. Copley SJ, Lee YCG, Hansell DM, Sivakumaran P, Rubens MB, Newman Taylor AJ, et al. Asbestosis-induced and smoking-related disease: apportioning pulmonary function deficit by using thin-section CT. Radiology. 2007;242:258–266
  11. Gevenois PA, De Vuyst P, de Maertelaer V, Zanen J, Jacobovitz D, Cosio MG, et al. Comparison of computed density and microscopic morphometry in pulmonary emphysema. Am J Respir Crit Care Med. 1996;154:187–192
  12. American Thoracic Society. Lung function testing: selection of reference values and interpretative strategies. Am Rev Respir Dis. 1991;144:1202–1218
  13. Pauwels RA, Buist AS, Calverley PM, Jenkins CR, Hurd SS, GOLD Scientific Committee . Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. NHLBI/WHO Global Initiative for chronic obstructive lung disease (GOLD) workshop summary. Am J Respir Crit Care Med. 2001;163:1256–1276
  14. Sachs L. Weitere Anwendungen der z-Transformation. In:  Sachs L editors. Angewandte Statistik [German]. 10th ed.. Heidelberg Berlin: Springer; 2002;p. 543–547
  15. Gietema HA, Schilham AM, van Ginneken B, van Klaveren RJ, Lammers JW, Prokop M. Monitoring of smoking-induced emphysema with CT in a lung cancer screening setting: detection of real increase in extent of emphysema. Radiology. 2007;244:890–897
  16. Ley-Zaporozhan J, Ley S, Kauczor H-U. Morphological and functional imaging in COPD with CT and MRI: present and future. Eur Radiol. 2008;18:510–521
  17. Kurashima K, Takayanagi N, Sato N, Kanauchi T, Hoshi T, Tokunaga D, et al. High resolution CT and bronchial reversibility test for diagnosing COPD. Respirology. 2005;10:316–322
  18. Kuhnigk J-M, Dicken V, Zidowitz S, Bornemann L, Kuemmerlen B, Krass S, et al. Informatics in radiology (infoRAD): new tools for computer assistance in thoracic CT. Part 1. Functional analysis of lungs, lung lobes, and bronchopulmonary segments. Radiographics. 2005;25:525–536
  19. Desai SR, Hansell DM, Walker A, MacDonald SL, Chabat F, Wells AU. Quantification of emphysema: a composite physiologic index derived from CT estimation of disease extent. Eur Radiol. 2007;17:911–918
  20. Shaker SB, Dirksen A, Laursen LC, Maltbaek N, Christensen L, Sander U, et al. Short-term reproducibility of computed tomography-based lung density measurements in alpha-1 antitrypsin deficiency and smokers with emphysema. Acta Radiol. 2004;45:424–430
  21. Kalender WA, Rienmüller R, Seissler W, Behr J, Welke M, Fichte H. Measurement of pulmonary parenchymal attenuation: use of spirometric gating with quantitative CT. Radiology. 1990;175:265–268
  22. Moroni C, Mascalchi M, Camiciottoli G, Bartollucci M, Falaschi F, Battolla L, et al. Comparison of spirometric-gated and -ungated HRCT in COPD. J Comput Assist Tomogr. 2003;27:375–379
  23. Kauczor HU, Hast J, Heussel CP, Schlegel J, Mildenberger P, Thelen M. CT attenuation of paired HRCT scans obtained at full inspiratory/expiratory position: comparison with pulmonary function tests. Eur Radiol. 2002;12:2757–2763
  24. Zaporozhan J, Ley S, Eberhardt R, Weinheimer O, Iliyushenko S, Herth F, et al. Paired inspiratory/expiratory volumetric thin-slice CT scan for emphysema analysis: comparison of different quantitative evaluations and pulmonary function test. Chest. 2005;128:3212–3220
  25. Camiciottoli G, Bartolucci M, Maluccio NM, Moroni C, Mascalchi M, Giuntini C, et al. Spirometrically gated high-resolution CT findings in COPD—lung attenuation vs lung function and dyspnea severity. Chest. 2006;129:558–564
  26. Das M, Mahnken AH, Mühlenbruch G, Stargardt A, Weiss C, Sennst DA, et al. Individually adapted examination protocols for reduction of radiation exposure for 16-MDCT chest examinations. Am J Roentgenol. 2005;184:1437–1443
  27. Gierada DS, Pilgram TK, Whiting BR, Hong C, Bierhals AJ, Kim JH, et al. Comparison of standard- and low-radiation-dose CT for quantification of emphysema. Am J Roentgenol. 2007;188:42–47
  28. Madani A, De Maertelaer V, Zanen J, Gevenois PA. Pulmonary emphysema: radiation dose and section thickness at multidetector CT quantification—comparison with macroscopic and microscopic morphometry. Radiology. 2007;243:250–257
  29. Kuwano K, Matsuba K, Ikeda T, Murakami J, Araki A, Nishintani H, et al. The diagnosis of mild emphysema. Correlation of computed tomography and pathology scores. Am Rev Respir Dis. 1990;141:169–178
  30. Bergin C, Müller N, Nichols DM, Lillington G, Hogg JC, Mullen B, et al. The diagnosis of emphysema. A computed tomographic–pathologic correlation. Am Rev Respir Dis. 1986;133:541–546
  31. Dransfield MT, Washko GR, Foreman MG, Estepar RS, Reilly J, Bailey WC. Gender differences in the severity of CT emphysema in COPD. Chest. 2007;132:464–470
  32. Berger P, Perot V, Desbarats P, Tunon-de-Lara JM, Marthan R, Laurent F. Airway wall thickness in cigarette smokers: quantitative thin-section CT assessment. Radiology. 2005;235:1055–1064
  33. Orlandi I, Moroni C, Camiciottoli G, Bartolucci M, Pistolesi M, Villari N, et al. Chronic obstructive pulmonary disease: thin-section CT measurement of airway wall thickness and lung attenuation. Radiology. 2005;234:604–610
  34. Stolk J, Putter H, Bakker EM, Shaker SB, Parr DG, Piitulainen E, et al. Progression parameters for emphysema: a clinical investigation. Respiratory Medicine. 2007;101:1924–1930
  35. Ong KC, Lu SJ, Soh CS. Does the multidimensional grading system (BODE) correspond to differences in health status of patients with COPD?. Int J Chron Obstruct Pulmon Dis. 2006;1:91–96

PII: S0899-7071(09)00121-1

doi: 10.1016/j.clinimag.2009.05.004

Clinical Imaging
Volume 34, Issue 3 , Pages 172-178 , May 2010

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